Macrocyclic HOPO chelators


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Nathaniel G. Butlin , Kenneth N. Raymond , Jide Xu , Anthony D'Aleo

ABSTRACT

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. More... »

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