Engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Sang Yup Lee , Sung Won Lim , Hyohak Song

ABSTRACT

The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia, genus Actinobacillus and genus Anaerobiospirillum, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration while producing little or no other organic acids in anaerobic conditions, which is obtained by disrupting a gene encoding lactate dehydrogenase (ldhA), a gene encoding phosphotransacetylase (pta), and a gene encoding acetate kinase (ackA), without disrupting a gene encoding pyruvate formate lyase (pfl), as well as a method for producing succinic acid using the same. The inventive mutant microorganism has the property of having a high growth rate and succinic acid productivity while producing little or no organic acids, as compared to the prior strains producing succinic acid. Thus, the inventive mutant microorganism is useful to produce succinic acid for industrial use. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Sang Yup Lee", 
        "type": "Person"
      }, 
      {
        "name": "Sung Won Lim", 
        "type": "Person"
      }, 
      {
        "name": "Hyohak Song", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00253-004-1733-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000433309", 
          "https://doi.org/10.1007/s00253-004-1733-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010954636", 
          "https://doi.org/10.1038/nbt1010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002030050452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025496257", 
          "https://doi.org/10.1007/s002030050452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.72.3.1939-1948.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028380112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002530051431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036378299", 
          "https://doi.org/10.1007/s002530051431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mmbr.69.1.12-50.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049605303"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "description": "

The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia, genus Actinobacillus and genus Anaerobiospirillum, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration while producing little or no other organic acids in anaerobic conditions, which is obtained by disrupting a gene encoding lactate dehydrogenase (ldhA), a gene encoding phosphotransacetylase (pta), and a gene encoding acetate kinase (ackA), without disrupting a gene encoding pyruvate formate lyase (pfl), as well as a method for producing succinic acid using the same. The inventive mutant microorganism has the property of having a high growth rate and succinic acid productivity while producing little or no organic acids, as compared to the prior strains producing succinic acid. Thus, the inventive mutant microorganism is useful to produce succinic acid for industrial use.

", "id": "sg:patent.US-9217138-B2", "keywords": [ "engineered microorganism", "Succinic Acid", "method", "invention", "microorganism", "genus", "high concentration", "organic acid", "anaerobic condition", "gene", "L-Lactate Dehydrogenase", "acetyltransferase", "PTA", "acetate kinase", "pyruvate formate-lyase", "high growth rate", "industrial use" ], "name": "Engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.37172.30", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-9217138-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:33", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_2f12e043.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-9217138-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-9217138-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-9217138-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-9217138-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

68 TRIPLES      14 PREDICATES      36 URIs      24 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-9217138-B2 schema:about anzsrc-for:2620
2 schema:author Nf20133df14a244d6a6a777e0f00006f3
3 schema:citation sg:pub.10.1007/s002030050452
4 sg:pub.10.1007/s00253-004-1733-0
5 sg:pub.10.1007/s002530051431
6 sg:pub.10.1038/nbt1010
7 https://doi.org/10.1128/aem.72.3.1939-1948.2006
8 https://doi.org/10.1128/mmbr.69.1.12-50.2005
9 schema:description <p id="p-0001" num="0000">The present invention relates to a mutant microorganism, which is selected from the group consisting of genus <i>Mannheimia</i>, genus <i>Actinobacillus </i>and genus <i>Anaerobiospirillum</i>, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration while producing little or no other organic acids in anaerobic conditions, which is obtained by disrupting a gene encoding lactate dehydrogenase (ldhA), a gene encoding phosphotransacetylase (pta), and a gene encoding acetate kinase (ackA), without disrupting a gene encoding pyruvate formate lyase (pfl), as well as a method for producing succinic acid using the same. The inventive mutant microorganism has the property of having a high growth rate and succinic acid productivity while producing little or no organic acids, as compared to the prior strains producing succinic acid. Thus, the inventive mutant microorganism is useful to produce succinic acid for industrial use.</p>
10 schema:keywords L-Lactate Dehydrogenase
11 PTA
12 Succinic Acid
13 acetate kinase
14 acetyltransferase
15 anaerobic condition
16 engineered microorganism
17 gene
18 genus
19 high concentration
20 high growth rate
21 industrial use
22 invention
23 method
24 microorganism
25 organic acid
26 pyruvate formate-lyase
27 schema:name Engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same
28 schema:recipient https://www.grid.ac/institutes/grid.37172.30
29 schema:sameAs https://app.dimensions.ai/details/patent/US-9217138-B2
30 schema:sdDatePublished 2019-03-07T15:33
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher Nd62816119a7d4bcfb865d54061d2b950
33 sgo:license sg:explorer/license/
34 sgo:sdDataset patents
35 rdf:type sgo:Patent
36 N237119e28774411db9a5ba6329a3173b rdf:first Nc5aacbef4c4042e798f65a2aba869f16
37 rdf:rest rdf:nil
38 N48579bf28f8c4e11ab1a156c1ae55796 schema:name Sang Yup Lee
39 rdf:type schema:Person
40 N5a71cc8a63624635aeb767101f04bedb rdf:first Ndb93599658bd46408f1ec928a732f314
41 rdf:rest N237119e28774411db9a5ba6329a3173b
42 Nc5aacbef4c4042e798f65a2aba869f16 schema:name Hyohak Song
43 rdf:type schema:Person
44 Nd62816119a7d4bcfb865d54061d2b950 schema:name Springer Nature - SN SciGraph project
45 rdf:type schema:Organization
46 Ndb93599658bd46408f1ec928a732f314 schema:name Sung Won Lim
47 rdf:type schema:Person
48 Nf20133df14a244d6a6a777e0f00006f3 rdf:first N48579bf28f8c4e11ab1a156c1ae55796
49 rdf:rest N5a71cc8a63624635aeb767101f04bedb
50 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
51 rdf:type schema:DefinedTerm
52 sg:pub.10.1007/s002030050452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025496257
53 https://doi.org/10.1007/s002030050452
54 rdf:type schema:CreativeWork
55 sg:pub.10.1007/s00253-004-1733-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000433309
56 https://doi.org/10.1007/s00253-004-1733-0
57 rdf:type schema:CreativeWork
58 sg:pub.10.1007/s002530051431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036378299
59 https://doi.org/10.1007/s002530051431
60 rdf:type schema:CreativeWork
61 sg:pub.10.1038/nbt1010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010954636
62 https://doi.org/10.1038/nbt1010
63 rdf:type schema:CreativeWork
64 https://doi.org/10.1128/aem.72.3.1939-1948.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028380112
65 rdf:type schema:CreativeWork
66 https://doi.org/10.1128/mmbr.69.1.12-50.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049605303
67 rdf:type schema:CreativeWork
68 https://www.grid.ac/institutes/grid.37172.30 schema:Organization
 




Preview window. Press ESC to close (or click here)


...