Method of inactivating a glucocorticoid receptor gene in an isolated cell


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Andreas Reik , Michael Jensen , Michael C. Holmes , Philip D. Gregory , Dale Ando

ABSTRACT

Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

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