Methods and compositions in particle-based detection of target molecules using linking molecules


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Celine Hu , Jianping Xu , Hetian Gao , Julie Perkins

ABSTRACT

Methods and compositions which can be used to increase the strength and/or probability of forming a binding complex comprising a target molecule and a substrate are disclosed. In one aspect, linking molecules are disclosed which can be used to increase the number of intra-complex binding interactions. Covalent bonds can be introduced to further increase the strength of these binding interactions. Inter-complex cross-linking can be utilized in connection with these methods to further strengthen and stabilize the disclosed binding complexes. More... »

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