ICOS critically regulates the expansion and function of inflammatory human Th17 cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

James L. Riley , Chrystal Paulos , Carl H. June , Bruce Levine

ABSTRACT

The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents. More... »

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