Notch1 binding agents and methods of use thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2015-09-15T00:00

AUTHORS

VAN DER HORST EDWARD THEIN HTUN , GURNEY AUSTIN L , HOEY TIMOTHY CHARLES , BRUHNS MAUREEN FITCH , AXELROD FUMIKO TAKADA

ABSTRACT

The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia. More... »

Related SciGraph Publications

  • 1998-05. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain in NATURE
  • 1992-07-01. By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling in BIO/TECHNOLOGY
  • 2009-04-09. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia in LEUKEMIA
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • 2005-06-06. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells in ONCOGENE
  • 1996-03. Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library in NATURE BIOTECHNOLOGY
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2007-01-12. Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells in HISTOCHEMISTRY AND CELL BIOLOGY
  • 1995-09. Signalling downstream of activated mammalian Notch in NATURE
  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
  • 1975-08. Continuous cultures of fused cells secreting antibody of predefined specificity in NATURE
  • 1988-03. Reshaping human antibodies for therapy in NATURE
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 1991-08. Making antibody fragments using phage display libraries in NATURE
  • 2000-06-29. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays in ONCOGENE
  • 2007-04-01. Structural basis for autoinhibition of Notch in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-06. Notch signals control the fate of immature progenitor cells in the intestine in NATURE
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2007-02-14. Vessel guidance in NATURE
  • 2000-01-13. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines in ONCOGENE
  • 1999-10. Defining epitopes: It's not as easy as it seems in NATURE BIOTECHNOLOGY
  • 2003-09-29. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents in ONCOGENE
  • 2006-04-13. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia in NATURE REVIEWS CANCER
  • 2005-08-23. The Notch pathway in ovarian carcinomas and adenomas in BRITISH JOURNAL OF CANCER
  • 2005-06. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells in NATURE
  • 1983-10. Hybrid hybridomas and their use in immunohistochemistry in NATURE
  • 2010-04. Therapeutic antibody targeting of individual Notch receptors in NATURE
  • 2008-09-01. Notch3: from subtle structural differences to functional diversity in ONCOGENE
  • 2005-06-12. Notch signaling controls the generation and differentiation of early T lineage progenitors in NATURE IMMUNOLOGY
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