Detection and quantification of biomolecules using mass spectrometry


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Dirk Johannes VAN DEN BOOM , Paul Andrew Oeth , Payam Mahboubi

ABSTRACT

The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids. More... »

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