Monoclonal antibody that binds human notch2 and notch3


Ontology type: sgo:Patent     


Patent Info

DATE

2015-03-17T00:00

AUTHORS

GURNEY AUSTIN L , HOEY TIMOTHY CHARLES , VAN DER HORST EDWARD THEIN HTUN , SATO AARON KEN , LIU YUAN CHING , BRUHNS MAUREEN FITCH , LEWICKI JOHN A

ABSTRACT

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. More... »

Related SciGraph Publications

  • 1992-07-01. By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling in BIO/TECHNOLOGY
  • 2009-04-09. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia in LEUKEMIA
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • 2005-06-06. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells in ONCOGENE
  • 1996-03. Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library in NATURE BIOTECHNOLOGY
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2007-01-12. Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells in HISTOCHEMISTRY AND CELL BIOLOGY
  • 1995-09. Signalling downstream of activated mammalian Notch in NATURE
  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
  • 1975-08. Continuous cultures of fused cells secreting antibody of predefined specificity in NATURE
  • 1988-03. Reshaping human antibodies for therapy in NATURE
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 1991-08. Making antibody fragments using phage display libraries in NATURE
  • 2000-06-29. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays in ONCOGENE
  • 2007-04-01. Structural basis for autoinhibition of Notch in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-06. Notch signals control the fate of immature progenitor cells in the intestine in NATURE
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2007-02-14. Vessel guidance in NATURE
  • 2000-01-13. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines in ONCOGENE
  • 1999-10. Defining epitopes: It's not as easy as it seems in NATURE BIOTECHNOLOGY
  • 2003-09-29. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents in ONCOGENE
  • 2006-04-13. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia in NATURE REVIEWS CANCER
  • 2005-06-12. Notch signaling controls the generation and differentiation of early T lineage progenitors in NATURE IMMUNOLOGY
  • 2005-06. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells in NATURE
  • 1983-10. Hybrid hybridomas and their use in immunohistochemistry in NATURE
  • 2010-04. Therapeutic antibody targeting of individual Notch receptors in NATURE
  • 2005-08-23. The Notch pathway in ovarian carcinomas and adenomas in BRITISH JOURNAL OF CANCER
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "GURNEY AUSTIN L", 
            "type": "Person"
          }, 
          {
            "name": "HOEY TIMOTHY CHARLES", 
            "type": "Person"
          }, 
          {
            "name": "VAN DER HORST EDWARD THEIN HTUN", 
            "type": "Person"
          }, 
          {
            "name": "SATO AARON KEN", 
            "type": "Person"
          }, 
          {
            "name": "LIU YUAN CHING", 
            "type": "Person"
          }, 
          {
            "name": "BRUHNS MAUREEN FITCH", 
            "type": "Person"
          }, 
          {
            "name": "LEWICKI JOHN A", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/13590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043526173", 
              "https://doi.org/10.1038/13590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026135489", 
              "https://doi.org/10.1038/nature08878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0396-309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022704505", 
              "https://doi.org/10.1038/nbt0396-309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0792-779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007019873", 
              "https://doi.org/10.1038/nbt0792-779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053478064", 
              "https://doi.org/10.1038/sj.onc.1203295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424763", 
              "https://doi.org/10.1038/ni1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-006-0260-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015583094", 
              "https://doi.org/10.1007/s00418-006-0260-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367645a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028822583", 
              "https://doi.org/10.1038/367645a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050959167", 
              "https://doi.org/10.1038/nrc1880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013090465", 
              "https://doi.org/10.1038/nm754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046925751", 
              "https://doi.org/10.1038/sj.bjc.6602719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2009.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047081856", 
              "https://doi.org/10.1038/leu.2009.75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35102167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021100179", 
              "https://doi.org/10.1038/35102167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/305537a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010169967", 
              "https://doi.org/10.1038/305537a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018549599", 
              "https://doi.org/10.1038/sj.onc.1206758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/445722a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002673152", 
              "https://doi.org/10.1038/445722a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377355a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019765251", 
              "https://doi.org/10.1038/377355a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383707a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043218935", 
              "https://doi.org/10.1038/383707a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043382175", 
              "https://doi.org/10.1038/ni1216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012634585", 
              "https://doi.org/10.1038/sj.onc.1208783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/81390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039701921", 
              "https://doi.org/10.1038/81390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046707660", 
              "https://doi.org/10.1038/nature03659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014955709", 
              "https://doi.org/10.1038/nsmb1227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/332323a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016704652", 
              "https://doi.org/10.1038/332323a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/352624a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021945431", 
              "https://doi.org/10.1038/352624a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029200703", 
              "https://doi.org/10.1038/sj.onc.1203703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015449829", 
              "https://doi.org/10.1038/nature03589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/256495a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001387921", 
              "https://doi.org/10.1038/256495a0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-03-17T00:00", 
        "description": "

    The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

    ", "endDate": "2029-07-08", "id": "sg:patent.US-8980260-B2", "name": "Monoclonal antibody that binds human notch2 and notch3", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.467496.e", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8980260-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_12.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8980260-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8980260-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8980260-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8980260-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    162 TRIPLES      15 PREDICATES      44 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-8980260-B2 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N4f457df9745841e5b7d8960c788db9c7
    4 schema:citation sg:pub.10.1007/s00418-006-0260-8
    5 sg:pub.10.1038/13590
    6 sg:pub.10.1038/256495a0
    7 sg:pub.10.1038/305537a0
    8 sg:pub.10.1038/332323a0
    9 sg:pub.10.1038/35102167
    10 sg:pub.10.1038/352624a0
    11 sg:pub.10.1038/367645a0
    12 sg:pub.10.1038/377355a0
    13 sg:pub.10.1038/383707a0
    14 sg:pub.10.1038/445722a
    15 sg:pub.10.1038/81390
    16 sg:pub.10.1038/leu.2009.75
    17 sg:pub.10.1038/nature03589
    18 sg:pub.10.1038/nature03659
    19 sg:pub.10.1038/nature08878
    20 sg:pub.10.1038/nbt0396-309
    21 sg:pub.10.1038/nbt0792-779
    22 sg:pub.10.1038/ni1164
    23 sg:pub.10.1038/ni1216
    24 sg:pub.10.1038/nm754
    25 sg:pub.10.1038/nrc1880
    26 sg:pub.10.1038/nsmb1227
    27 sg:pub.10.1038/sj.bjc.6602719
    28 sg:pub.10.1038/sj.onc.1203295
    29 sg:pub.10.1038/sj.onc.1203703
    30 sg:pub.10.1038/sj.onc.1206758
    31 sg:pub.10.1038/sj.onc.1208783
    32 schema:datePublished 2015-03-17T00:00
    33 schema:description <p num="p-0001">The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.</p>
    34 schema:endDate 2029-07-08
    35 schema:name Monoclonal antibody that binds human notch2 and notch3
    36 schema:recipient grid-institutes:grid.467496.e
    37 schema:sameAs https://app.dimensions.ai/details/patent/US-8980260-B2
    38 schema:sdDatePublished 2022-09-02T16:21
    39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    40 schema:sdPublisher Nae644e05fd104c709e2354fa123fa0f7
    41 sgo:license sg:explorer/license/
    42 sgo:sdDataset patents
    43 rdf:type sgo:Patent
    44 N285a8b0d7449421fa28ad2561aea02ab rdf:first Nc33b9d08847c4f1492e96f58d90ea4e4
    45 rdf:rest N38110081ccca49fbb8ae9ccff7e27f1e
    46 N38110081ccca49fbb8ae9ccff7e27f1e rdf:first Nc516c2bb6c164d1f9f5898bfd6236552
    47 rdf:rest Na3b106e283e34220b12283cb5df67061
    48 N480ac4030a8845bf8fb6dd4fd699c62c schema:name LEWICKI JOHN A
    49 rdf:type schema:Person
    50 N4f457df9745841e5b7d8960c788db9c7 rdf:first Nf6a99000031e4b90afe3b8b313b5501a
    51 rdf:rest N9dc2a330aef44455848a3b1545c5145b
    52 N8e481c3ec0dc4dbfaf7ab8bfae08e290 schema:name SATO AARON KEN
    53 rdf:type schema:Person
    54 N94c6e75bc00d4176aaa26a19b4fdb559 rdf:first N8e481c3ec0dc4dbfaf7ab8bfae08e290
    55 rdf:rest N285a8b0d7449421fa28ad2561aea02ab
    56 N9dc2a330aef44455848a3b1545c5145b rdf:first Nc26e25cc73a7486fb050b5cdd36e83be
    57 rdf:rest Naf3ea9c4b9f841c28f881dd53241c226
    58 Na3b106e283e34220b12283cb5df67061 rdf:first N480ac4030a8845bf8fb6dd4fd699c62c
    59 rdf:rest rdf:nil
    60 Nae644e05fd104c709e2354fa123fa0f7 schema:name Springer Nature - SN SciGraph project
    61 rdf:type schema:Organization
    62 Naf3ea9c4b9f841c28f881dd53241c226 rdf:first Nf07c0242e0b14d178a95fd45cf2476af
    63 rdf:rest N94c6e75bc00d4176aaa26a19b4fdb559
    64 Nc26e25cc73a7486fb050b5cdd36e83be schema:name HOEY TIMOTHY CHARLES
    65 rdf:type schema:Person
    66 Nc33b9d08847c4f1492e96f58d90ea4e4 schema:name LIU YUAN CHING
    67 rdf:type schema:Person
    68 Nc516c2bb6c164d1f9f5898bfd6236552 schema:name BRUHNS MAUREEN FITCH
    69 rdf:type schema:Person
    70 Nf07c0242e0b14d178a95fd45cf2476af schema:name VAN DER HORST EDWARD THEIN HTUN
    71 rdf:type schema:Person
    72 Nf6a99000031e4b90afe3b8b313b5501a schema:name GURNEY AUSTIN L
    73 rdf:type schema:Person
    74 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    75 rdf:type schema:DefinedTerm
    76 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    77 rdf:type schema:DefinedTerm
    78 sg:pub.10.1007/s00418-006-0260-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015583094
    79 https://doi.org/10.1007/s00418-006-0260-8
    80 rdf:type schema:CreativeWork
    81 sg:pub.10.1038/13590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043526173
    82 https://doi.org/10.1038/13590
    83 rdf:type schema:CreativeWork
    84 sg:pub.10.1038/256495a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001387921
    85 https://doi.org/10.1038/256495a0
    86 rdf:type schema:CreativeWork
    87 sg:pub.10.1038/305537a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010169967
    88 https://doi.org/10.1038/305537a0
    89 rdf:type schema:CreativeWork
    90 sg:pub.10.1038/332323a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016704652
    91 https://doi.org/10.1038/332323a0
    92 rdf:type schema:CreativeWork
    93 sg:pub.10.1038/35102167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100179
    94 https://doi.org/10.1038/35102167
    95 rdf:type schema:CreativeWork
    96 sg:pub.10.1038/352624a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021945431
    97 https://doi.org/10.1038/352624a0
    98 rdf:type schema:CreativeWork
    99 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
    100 https://doi.org/10.1038/367645a0
    101 rdf:type schema:CreativeWork
    102 sg:pub.10.1038/377355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019765251
    103 https://doi.org/10.1038/377355a0
    104 rdf:type schema:CreativeWork
    105 sg:pub.10.1038/383707a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043218935
    106 https://doi.org/10.1038/383707a0
    107 rdf:type schema:CreativeWork
    108 sg:pub.10.1038/445722a schema:sameAs https://app.dimensions.ai/details/publication/pub.1002673152
    109 https://doi.org/10.1038/445722a
    110 rdf:type schema:CreativeWork
    111 sg:pub.10.1038/81390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039701921
    112 https://doi.org/10.1038/81390
    113 rdf:type schema:CreativeWork
    114 sg:pub.10.1038/leu.2009.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047081856
    115 https://doi.org/10.1038/leu.2009.75
    116 rdf:type schema:CreativeWork
    117 sg:pub.10.1038/nature03589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015449829
    118 https://doi.org/10.1038/nature03589
    119 rdf:type schema:CreativeWork
    120 sg:pub.10.1038/nature03659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707660
    121 https://doi.org/10.1038/nature03659
    122 rdf:type schema:CreativeWork
    123 sg:pub.10.1038/nature08878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026135489
    124 https://doi.org/10.1038/nature08878
    125 rdf:type schema:CreativeWork
    126 sg:pub.10.1038/nbt0396-309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022704505
    127 https://doi.org/10.1038/nbt0396-309
    128 rdf:type schema:CreativeWork
    129 sg:pub.10.1038/nbt0792-779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007019873
    130 https://doi.org/10.1038/nbt0792-779
    131 rdf:type schema:CreativeWork
    132 sg:pub.10.1038/ni1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424763
    133 https://doi.org/10.1038/ni1164
    134 rdf:type schema:CreativeWork
    135 sg:pub.10.1038/ni1216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043382175
    136 https://doi.org/10.1038/ni1216
    137 rdf:type schema:CreativeWork
    138 sg:pub.10.1038/nm754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013090465
    139 https://doi.org/10.1038/nm754
    140 rdf:type schema:CreativeWork
    141 sg:pub.10.1038/nrc1880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050959167
    142 https://doi.org/10.1038/nrc1880
    143 rdf:type schema:CreativeWork
    144 sg:pub.10.1038/nsmb1227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014955709
    145 https://doi.org/10.1038/nsmb1227
    146 rdf:type schema:CreativeWork
    147 sg:pub.10.1038/sj.bjc.6602719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046925751
    148 https://doi.org/10.1038/sj.bjc.6602719
    149 rdf:type schema:CreativeWork
    150 sg:pub.10.1038/sj.onc.1203295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053478064
    151 https://doi.org/10.1038/sj.onc.1203295
    152 rdf:type schema:CreativeWork
    153 sg:pub.10.1038/sj.onc.1203703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029200703
    154 https://doi.org/10.1038/sj.onc.1203703
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1038/sj.onc.1206758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018549599
    157 https://doi.org/10.1038/sj.onc.1206758
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1038/sj.onc.1208783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012634585
    160 https://doi.org/10.1038/sj.onc.1208783
    161 rdf:type schema:CreativeWork
    162 grid-institutes:grid.467496.e schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...