Primate pluripotent stem cell expansion without feeder cells and in the presence of FGF and matrigel or Engelbreth-Holm-Swarm tumor cell ...


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Ramkumar Mandalam , Chunhui Xu , Joseph D. Gold , Melissa K. Carpenter

ABSTRACT

This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to the culture environment that support rapid proliferation without differentiation. Effective features are a suitable support structure for the cells, and an effective medium that can be added fresh to the culture without being preconditioned by another cell type. Culturing human embryonic stem cells in fresh medium according to this invention causes the cells to expand surprisingly rapidly, while retaining the ability to differentiate into cells representing all three embryonic germ layers. This new culture system allows for bulk proliferation of pPS cells for commercial production of important products for use in drug screening and human therapy. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2995", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Ramkumar Mandalam", 
        "type": "Person"
      }, 
      {
        "name": "Chunhui Xu", 
        "type": "Person"
      }, 
      {
        "name": "Joseph D. Gold", 
        "type": "Person"
      }, 
      {
        "name": "Melissa K. Carpenter", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000301825", 
          "https://doi.org/10.1038/nm979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4781(96)00179-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000797092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.2001.7832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001522387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2004.08.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001805072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(00)00238-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001909129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1263/jbb.103.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001959967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.10431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003051610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-0016(02)00047-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003522622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.22-6-972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003528262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0311-05.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003990679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0963-6897(95)02040-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004818195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00392-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004929245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.950191005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005487443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.2000.4940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005539714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(84)90316-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005903517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.102.012583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006236439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(01)61687-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006693250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0015-0282(97)00438-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007312409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.103.021147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007519570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2001.060002568.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007629294", 
          "https://doi.org/10.1046/j.1523-1755.2001.060002568.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008652652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009583211", 
          "https://doi.org/10.1038/nbt726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.98.1.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009624166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1996.0167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010227520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010512439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/336688a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010804374", 
          "https://doi.org/10.1038/336688a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90443-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010910482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/23.7.1273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011017063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-10-4065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011381855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(96)00596-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012463025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90317-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012682609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012991943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013128911", 
          "https://doi.org/10.1038/nbt788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013615503", 
          "https://doi.org/10.1038/nature05142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.21-2-131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014191723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1001-971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014515248", 
          "https://doi.org/10.1038/nbt1001-971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014531479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1071/rd9940543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014678600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(90)90390-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014909389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0185(19990815)257:4<137::aid-ar7>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015156342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.22-4-433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015160843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910580118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016077100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0592-534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016342065", 
          "https://doi.org/10.1038/nbt0592-534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1994.1338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016443136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/jrf.0.0910423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017421565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/292154a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017487986", 
          "https://doi.org/10.1038/292154a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4773(95)00446-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017548642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.17.7844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018395893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66473-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019112974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2006.04397.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020153841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.25.14863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020882317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021378655", 
          "https://doi.org/10.1038/nbt1189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.32.19475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021554252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.14.8175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021684038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.03.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021906730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-169x.1999.00412.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022290828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.23.13726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022938582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1201-1129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023182407", 
          "https://doi.org/10.1038/nbt1201-1129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1998.tb01330.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023474053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1994.1585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023535032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrd.1080380304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023683602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1472-6483(10)61772-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024151595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024628851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.21-3-257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025112128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/asheducation-2002.1.369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025334190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01666137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026225001", 
          "https://doi.org/10.1007/bf01666137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01666137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026225001", 
          "https://doi.org/10.1007/bf01666137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02619423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026557976", 
          "https://doi.org/10.1007/bf02619423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1998.4025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026614548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2004.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026661183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1997.6674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027312549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2007.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028149787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1615-9861(200209)2:9<1187::aid-prot1187>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028340527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.282.5391.1145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028898955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(95)00719-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029660815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1995.1113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029840797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0012-1606(03)00256-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030212846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08977199709021517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030296154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030407065", 
          "https://doi.org/10.1038/nbt1177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.18.3745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030812400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000035254.80718.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032098280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033196590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00393-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033478972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1994.1478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033522208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.15.4261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033558568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033604670", 
          "https://doi.org/10.1038/74447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.21.11307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034054816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035860884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036210003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.20045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037461335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037634240", 
          "https://doi.org/10.1038/nbt1197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0955-0674(95)80071-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037985643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.26.14809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038291620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.7.3817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038581668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.22-3-275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038674692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/336684a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038677733", 
          "https://doi.org/10.1038/336684a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.20536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039000239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0177(199806)212:2<181::aid-aja4>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039456259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039506700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039527876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0922-3371(90)90139-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039726001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1071/r98041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040018751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2795(199601)43:1<7::aid-mrd2>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041375080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0290(20000920)69:6<607::aid-bit4>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041459541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-4666(94)90007-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041731376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042314581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042641866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1995.1085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043275723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep.1.00243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043535746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep.1.00243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043535746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-1656(90)90049-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044032205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2795(200006)56:2<113::aid-mrd1>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044786323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045135667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.490410610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046266879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.22.10778-10784.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046618290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.45.32192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046702156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0185(19990215)257:1<32::aid-ar6>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047195256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1998.4353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047253151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(01)00144-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047314499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.12.7029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048019417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2005.01.086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048198913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.11.5709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048203018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.37.24095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048257524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.19-3-193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048315607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.10430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048489083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048582243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.21-5-546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050445045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5349.349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051728512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.21-1-111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051806446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(87)90132-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051881908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(89)90245-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051950796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/deg290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052424641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(98)70399-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053505955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2000.9912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053693663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi960930o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055212102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.282.5386.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062562632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.282.5391.1061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062563099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.285.5428.754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062566123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8235591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1387/ijdb.052107cd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067190628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-06-0087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067716799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-06-0087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067716799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.humrep.a136971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079346599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.humrep.a138401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082543244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-03-01056.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082858595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.10.14.9002557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083034718"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "description": "

This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to the culture environment that support rapid proliferation without differentiation. Effective features are a suitable support structure for the cells, and an effective medium that can be added fresh to the culture without being preconditioned by another cell type. Culturing human embryonic stem cells in fresh medium according to this invention causes the cells to expand surprisingly rapidly, while retaining the ability to differentiate into cells representing all three embryonic germ layers. This new culture system allows for bulk proliferation of pPS cells for commercial production of important products for use in drug screening and human therapy.

", "id": "sg:patent.US-8951800-B2", "keywords": [ "pluripotent stem cell", "feeder cell", "FGF", "Matrigel", "cell preparation", "disclosure", "improved system", "human pluripotent stem cell", "layer", "mouse embryonic fibroblast", "component", "culture environment", "rapid proliferation", "feature", "cell", "effective medium", "culture", "cell type", "human embryonic stem cell", "medium", "invention", "Germ Layer", "culture system", "proliferation", "commercial production", "important product", "Preclinical Drug Evaluation", "human therapy" ], "name": "Primate pluripotent stem cell expansion without feeder cells and in the presence of FGF and matrigel or Engelbreth-Holm-Swarm tumor cell preparation", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.423065.6", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8951800-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:34", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_962f20a5.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8951800-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8951800-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8951800-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8951800-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

510 TRIPLES      14 PREDICATES      185 URIs      35 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-8951800-B2 schema:about anzsrc-for:2581
2 anzsrc-for:2995
3 schema:author N93efad4ad4014bb0ad2959c368392b92
4 schema:citation sg:pub.10.1007/bf01666137
5 sg:pub.10.1007/bf02619423
6 sg:pub.10.1038/292154a0
7 sg:pub.10.1038/336684a0
8 sg:pub.10.1038/336688a0
9 sg:pub.10.1038/74447
10 sg:pub.10.1038/nature05142
11 sg:pub.10.1038/nbt0592-534
12 sg:pub.10.1038/nbt1001-971
13 sg:pub.10.1038/nbt1177
14 sg:pub.10.1038/nbt1189
15 sg:pub.10.1038/nbt1197
16 sg:pub.10.1038/nbt1201-1129
17 sg:pub.10.1038/nbt726
18 sg:pub.10.1038/nbt788
19 sg:pub.10.1038/nm979
20 sg:pub.10.1046/j.1523-1755.2001.060002568.x
21 https://doi.org/10.1002/(sici)1097-0177(199806)212:2<181::aid-aja4>3.0.co;2-d
22 https://doi.org/10.1002/(sici)1097-0185(19990215)257:1<32::aid-ar6>3.0.co;2-2
23 https://doi.org/10.1002/(sici)1097-0185(19990815)257:4<137::aid-ar7>3.0.co;2-q
24 https://doi.org/10.1002/(sici)1098-2795(199601)43:1<7::aid-mrd2>3.0.co;2-w
25 https://doi.org/10.1002/(sici)1098-2795(200006)56:2<113::aid-mrd1>3.0.co;2-q
26 https://doi.org/10.1002/1097-0290(20000920)69:6<607::aid-bit4>3.0.co;2-f
27 https://doi.org/10.1002/1615-9861(200209)2:9<1187::aid-prot1187>3.0.co;2-t
28 https://doi.org/10.1002/bies.950191005
29 https://doi.org/10.1002/bit.20045
30 https://doi.org/10.1002/bit.20536
31 https://doi.org/10.1002/dvdy.10430
32 https://doi.org/10.1002/dvdy.10431
33 https://doi.org/10.1002/ijc.2910580118
34 https://doi.org/10.1002/jnr.490410610
35 https://doi.org/10.1002/mrd.1080380304
36 https://doi.org/10.1006/bbrc.1994.1585
37 https://doi.org/10.1006/dbio.1995.1085
38 https://doi.org/10.1006/dbio.1995.1113
39 https://doi.org/10.1006/dbio.1996.0167
40 https://doi.org/10.1006/dbio.2000.9912
41 https://doi.org/10.1006/excr.1994.1338
42 https://doi.org/10.1006/excr.1998.4025
43 https://doi.org/10.1006/excr.1998.4353
44 https://doi.org/10.1006/excr.2000.4940
45 https://doi.org/10.1006/exnr.1997.6674
46 https://doi.org/10.1006/exnr.2001.7832
47 https://doi.org/10.1006/geno.1994.1478
48 https://doi.org/10.1016/0012-1606(84)90316-6
49 https://doi.org/10.1016/0012-1606(87)90132-1
50 https://doi.org/10.1016/0012-1606(90)90390-5
51 https://doi.org/10.1016/0014-4827(89)90245-0
52 https://doi.org/10.1016/0092-8674(87)90443-0
53 https://doi.org/10.1016/0092-8674(92)90317-6
54 https://doi.org/10.1016/0168-1656(90)90049-h
55 https://doi.org/10.1016/0378-1119(95)00719-9
56 https://doi.org/10.1016/0922-3371(90)90139-n
57 https://doi.org/10.1016/0925-4773(95)00446-8
58 https://doi.org/10.1016/0955-0674(95)80071-9
59 https://doi.org/10.1016/0963-6897(95)02040-3
60 https://doi.org/10.1016/1043-4666(94)90007-8
61 https://doi.org/10.1016/j.bbrc.2005.03.058
62 https://doi.org/10.1016/j.fertnstert.2004.09.004
63 https://doi.org/10.1016/j.fertnstert.2005.01.086
64 https://doi.org/10.1016/j.stem.2007.12.013
65 https://doi.org/10.1016/j.ydbio.2004.08.031
66 https://doi.org/10.1016/s0012-1606(03)00256-2
67 https://doi.org/10.1016/s0015-0282(97)00438-x
68 https://doi.org/10.1016/s0022-5347(01)61687-2
69 https://doi.org/10.1016/s0092-8674(03)00392-1
70 https://doi.org/10.1016/s0092-8674(03)00393-3
71 https://doi.org/10.1016/s0140-6736(05)66473-2
72 https://doi.org/10.1016/s0167-4781(96)00179-0
73 https://doi.org/10.1016/s0925-4773(96)00596-5
74 https://doi.org/10.1016/s0959-437x(00)00238-0
75 https://doi.org/10.1016/s0960-9822(01)00144-0
76 https://doi.org/10.1016/s0960-9822(98)70399-9
77 https://doi.org/10.1016/s1472-6483(10)61772-5
78 https://doi.org/10.1016/s1525-0016(02)00047-3
79 https://doi.org/10.1021/bi960930o
80 https://doi.org/10.1046/j.1440-169x.1999.00412.x
81 https://doi.org/10.1071/r98041
82 https://doi.org/10.1071/rd9940543
83 https://doi.org/10.1073/pnas.92.17.7844
84 https://doi.org/10.1073/pnas.94.11.5709
85 https://doi.org/10.1073/pnas.94.26.14809
86 https://doi.org/10.1073/pnas.95.14.8175
87 https://doi.org/10.1073/pnas.95.23.13726
88 https://doi.org/10.1073/pnas.95.25.14863
89 https://doi.org/10.1073/pnas.96.12.7029
90 https://doi.org/10.1073/pnas.97.21.11307
91 https://doi.org/10.1073/pnas.98.1.113
92 https://doi.org/10.1074/jbc.271.32.19475
93 https://doi.org/10.1074/jbc.273.37.24095
94 https://doi.org/10.1074/jbc.274.45.32192
95 https://doi.org/10.1093/emboj/18.15.4261
96 https://doi.org/10.1093/humrep/deg290
97 https://doi.org/10.1093/nar/23.7.1273
98 https://doi.org/10.1093/nar/25.18.3745
99 https://doi.org/10.1093/oxfordjournals.humrep.a136971
100 https://doi.org/10.1093/oxfordjournals.humrep.a138401
101 https://doi.org/10.1095/biolreprod.102.012583
102 https://doi.org/10.1095/biolreprod.103.021147
103 https://doi.org/10.1096/fasebj.10.14.9002557
104 https://doi.org/10.1111/j.1440-1681.2006.04397.x
105 https://doi.org/10.1111/j.1699-0463.1998.tb01330.x
106 https://doi.org/10.1126/science.279.5349.349
107 https://doi.org/10.1126/science.282.5386.115
108 https://doi.org/10.1126/science.282.5391.1061
109 https://doi.org/10.1126/science.282.5391.1145
110 https://doi.org/10.1126/science.285.5428.754
111 https://doi.org/10.1126/science.8235591
112 https://doi.org/10.1128/jvi.74.22.10778-10784.2000
113 https://doi.org/10.1128/mcb.17.7.3817
114 https://doi.org/10.1161/01.res.0000035254.80718.91
115 https://doi.org/10.1182/asheducation-2002.1.369
116 https://doi.org/10.1182/blood-2004-10-4065
117 https://doi.org/10.1242/dev.01706
118 https://doi.org/10.1242/jcs.02553
119 https://doi.org/10.1263/jbb.103.389
120 https://doi.org/10.1387/ijdb.052107cd
121 https://doi.org/10.1523/jneurosci.0311-05.2005
122 https://doi.org/10.1523/jneurosci.16-03-01056.1996
123 https://doi.org/10.1530/jrf.0.0910423
124 https://doi.org/10.1530/rep-06-0087
125 https://doi.org/10.1530/rep.1.00243
126 https://doi.org/10.1634/stemcells.19-3-193
127 https://doi.org/10.1634/stemcells.2004-0114
128 https://doi.org/10.1634/stemcells.2004-0137
129 https://doi.org/10.1634/stemcells.2004-0211
130 https://doi.org/10.1634/stemcells.2004-0279
131 https://doi.org/10.1634/stemcells.2004-0303
132 https://doi.org/10.1634/stemcells.2004-0338
133 https://doi.org/10.1634/stemcells.2004-0347
134 https://doi.org/10.1634/stemcells.2005-0034
135 https://doi.org/10.1634/stemcells.2005-0112
136 https://doi.org/10.1634/stemcells.2005-0247
137 https://doi.org/10.1634/stemcells.2005-0299
138 https://doi.org/10.1634/stemcells.2005-0398
139 https://doi.org/10.1634/stemcells.21-1-111
140 https://doi.org/10.1634/stemcells.21-2-131
141 https://doi.org/10.1634/stemcells.21-3-257
142 https://doi.org/10.1634/stemcells.21-5-546
143 https://doi.org/10.1634/stemcells.22-3-275
144 https://doi.org/10.1634/stemcells.22-4-433
145 https://doi.org/10.1634/stemcells.22-6-972
146 https://doi.org/10.3109/08977199709021517
147 schema:description <p num="p-0001">This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to the culture environment that support rapid proliferation without differentiation. Effective features are a suitable support structure for the cells, and an effective medium that can be added fresh to the culture without being preconditioned by another cell type. Culturing human embryonic stem cells in fresh medium according to this invention causes the cells to expand surprisingly rapidly, while retaining the ability to differentiate into cells representing all three embryonic germ layers. This new culture system allows for bulk proliferation of pPS cells for commercial production of important products for use in drug screening and human therapy.</p>
148 schema:keywords FGF
149 Germ Layer
150 Matrigel
151 Preclinical Drug Evaluation
152 cell
153 cell preparation
154 cell type
155 commercial production
156 component
157 culture
158 culture environment
159 culture system
160 disclosure
161 effective medium
162 feature
163 feeder cell
164 human embryonic stem cell
165 human pluripotent stem cell
166 human therapy
167 important product
168 improved system
169 invention
170 layer
171 medium
172 mouse embryonic fibroblast
173 pluripotent stem cell
174 proliferation
175 rapid proliferation
176 schema:name Primate pluripotent stem cell expansion without feeder cells and in the presence of FGF and matrigel or Engelbreth-Holm-Swarm tumor cell preparation
177 schema:recipient https://www.grid.ac/institutes/grid.423065.6
178 schema:sameAs https://app.dimensions.ai/details/patent/US-8951800-B2
179 schema:sdDatePublished 2019-03-07T15:34
180 schema:sdLicense https://scigraph.springernature.com/explorer/license/
181 schema:sdPublisher N71dbe08e9f9b40c19e2d0b992b2f9ae4
182 sgo:license sg:explorer/license/
183 sgo:sdDataset patents
184 rdf:type sgo:Patent
185 N164f81fe7e564f2690c0b102dbb8c045 schema:name Chunhui Xu
186 rdf:type schema:Person
187 N3d8eabcafd1440779fdf95bb58121b9a rdf:first Na680953eeb844f20849c58f03ad0c9d9
188 rdf:rest rdf:nil
189 N5afc07ffa8aa4d5ba9c45aadd369b484 rdf:first N164f81fe7e564f2690c0b102dbb8c045
190 rdf:rest N6f1104352b29482cb93f4156986f25d1
191 N6f1104352b29482cb93f4156986f25d1 rdf:first Nd548b0c7e5cb4ceeb9c356e7e908af22
192 rdf:rest N3d8eabcafd1440779fdf95bb58121b9a
193 N71dbe08e9f9b40c19e2d0b992b2f9ae4 schema:name Springer Nature - SN SciGraph project
194 rdf:type schema:Organization
195 N93efad4ad4014bb0ad2959c368392b92 rdf:first Nfb32d3a951ef469388837f2c4717cd87
196 rdf:rest N5afc07ffa8aa4d5ba9c45aadd369b484
197 Na680953eeb844f20849c58f03ad0c9d9 schema:name Melissa K. Carpenter
198 rdf:type schema:Person
199 Nd548b0c7e5cb4ceeb9c356e7e908af22 schema:name Joseph D. Gold
200 rdf:type schema:Person
201 Nfb32d3a951ef469388837f2c4717cd87 schema:name Ramkumar Mandalam
202 rdf:type schema:Person
203 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
204 rdf:type schema:DefinedTerm
205 anzsrc-for:2995 schema:inDefinedTermSet anzsrc-for:
206 rdf:type schema:DefinedTerm
207 sg:pub.10.1007/bf01666137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026225001
208 https://doi.org/10.1007/bf01666137
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/bf02619423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026557976
211 https://doi.org/10.1007/bf02619423
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/292154a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017487986
214 https://doi.org/10.1038/292154a0
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/336684a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038677733
217 https://doi.org/10.1038/336684a0
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/336688a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010804374
220 https://doi.org/10.1038/336688a0
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/74447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033604670
223 https://doi.org/10.1038/74447
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nature05142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013615503
226 https://doi.org/10.1038/nature05142
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nbt0592-534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016342065
229 https://doi.org/10.1038/nbt0592-534
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nbt1001-971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014515248
232 https://doi.org/10.1038/nbt1001-971
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nbt1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030407065
235 https://doi.org/10.1038/nbt1177
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nbt1189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021378655
238 https://doi.org/10.1038/nbt1189
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nbt1197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037634240
241 https://doi.org/10.1038/nbt1197
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nbt1201-1129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023182407
244 https://doi.org/10.1038/nbt1201-1129
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nbt726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009583211
247 https://doi.org/10.1038/nbt726
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nbt788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013128911
250 https://doi.org/10.1038/nbt788
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nm979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000301825
253 https://doi.org/10.1038/nm979
254 rdf:type schema:CreativeWork
255 sg:pub.10.1046/j.1523-1755.2001.060002568.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007629294
256 https://doi.org/10.1046/j.1523-1755.2001.060002568.x
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/(sici)1097-0177(199806)212:2<181::aid-aja4>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1039456259
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/(sici)1097-0185(19990215)257:1<32::aid-ar6>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047195256
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/(sici)1097-0185(19990815)257:4<137::aid-ar7>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1015156342
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/(sici)1098-2795(199601)43:1<7::aid-mrd2>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1041375080
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/(sici)1098-2795(200006)56:2<113::aid-mrd1>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1044786323
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1002/1097-0290(20000920)69:6<607::aid-bit4>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1041459541
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/1615-9861(200209)2:9<1187::aid-prot1187>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1028340527
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/bies.950191005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005487443
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/bit.20045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037461335
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/bit.20536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039000239
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/dvdy.10430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048489083
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/dvdy.10431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003051610
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/ijc.2910580118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016077100
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/jnr.490410610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046266879
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/mrd.1080380304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023683602
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1006/bbrc.1994.1585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023535032
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1006/dbio.1995.1085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043275723
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1006/dbio.1995.1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029840797
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1006/dbio.1996.0167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010227520
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1006/dbio.2000.9912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053693663
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1006/excr.1994.1338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016443136
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1006/excr.1998.4025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026614548
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1006/excr.1998.4353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047253151
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1006/excr.2000.4940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005539714
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1006/exnr.1997.6674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027312549
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1006/exnr.2001.7832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001522387
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1006/geno.1994.1478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033522208
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/0012-1606(84)90316-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005903517
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/0012-1606(87)90132-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051881908
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/0012-1606(90)90390-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014909389
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/0014-4827(89)90245-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051950796
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/0092-8674(87)90443-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010910482
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/0092-8674(92)90317-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012682609
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/0168-1656(90)90049-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1044032205
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/0378-1119(95)00719-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029660815
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/0922-3371(90)90139-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1039726001
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/0925-4773(95)00446-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017548642
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/0955-0674(95)80071-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037985643
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/0963-6897(95)02040-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004818195
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/1043-4666(94)90007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041731376
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/j.bbrc.2005.03.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021906730
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/j.fertnstert.2004.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026661183
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/j.fertnstert.2005.01.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048198913
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/j.stem.2007.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028149787
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/j.ydbio.2004.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001805072
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/s0012-1606(03)00256-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030212846
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/s0015-0282(97)00438-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007312409
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/s0022-5347(01)61687-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006693250
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/s0092-8674(03)00392-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004929245
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/s0092-8674(03)00393-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033478972
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/s0140-6736(05)66473-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019112974
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0167-4781(96)00179-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000797092
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s0925-4773(96)00596-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012463025
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/s0959-437x(00)00238-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001909129
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/s0960-9822(01)00144-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047314499
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/s0960-9822(98)70399-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053505955
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/s1472-6483(10)61772-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024151595
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/s1525-0016(02)00047-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003522622
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1021/bi960930o schema:sameAs https://app.dimensions.ai/details/publication/pub.1055212102
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1046/j.1440-169x.1999.00412.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022290828
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1071/r98041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040018751
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1071/rd9940543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014678600
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1073/pnas.92.17.7844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018395893
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1073/pnas.94.11.5709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048203018
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1073/pnas.94.26.14809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038291620
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1073/pnas.95.14.8175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021684038
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1073/pnas.95.23.13726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022938582
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1073/pnas.95.25.14863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882317
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1073/pnas.96.12.7029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048019417
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1073/pnas.97.21.11307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034054816
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1073/pnas.98.1.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009624166
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1074/jbc.271.32.19475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021554252
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1074/jbc.273.37.24095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048257524
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1074/jbc.274.45.32192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046702156
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1093/emboj/18.15.4261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033558568
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1093/humrep/deg290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052424641
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1093/nar/23.7.1273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011017063
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1093/nar/25.18.3745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030812400
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1093/oxfordjournals.humrep.a136971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079346599
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1093/oxfordjournals.humrep.a138401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082543244
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1095/biolreprod.102.012583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006236439
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1095/biolreprod.103.021147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007519570
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1096/fasebj.10.14.9002557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083034718
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1111/j.1440-1681.2006.04397.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020153841
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1111/j.1699-0463.1998.tb01330.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023474053
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1126/science.279.5349.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051728512
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1126/science.282.5386.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562632
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1126/science.282.5391.1061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563099
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1126/science.282.5391.1145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028898955
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1126/science.285.5428.754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062566123
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1126/science.8235591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653725
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1128/jvi.74.22.10778-10784.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046618290
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1128/mcb.17.7.3817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038581668
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1161/01.res.0000035254.80718.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032098280
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1182/asheducation-2002.1.369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025334190
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1182/blood-2004-10-4065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011381855
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1242/dev.01706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033196590
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1242/jcs.02553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014531479
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1263/jbb.103.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001959967
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1387/ijdb.052107cd schema:sameAs https://app.dimensions.ai/details/publication/pub.1067190628
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1523/jneurosci.0311-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003990679
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1523/jneurosci.16-03-01056.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082858595
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1530/jrf.0.0910423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017421565
463 rdf:type schema:CreativeWork
464 https://doi.org/10.1530/rep-06-0087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067716799
465 rdf:type schema:CreativeWork
466 https://doi.org/10.1530/rep.1.00243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043535746
467 rdf:type schema:CreativeWork
468 https://doi.org/10.1634/stemcells.19-3-193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048315607
469 rdf:type schema:CreativeWork
470 https://doi.org/10.1634/stemcells.2004-0114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039527876
471 rdf:type schema:CreativeWork
472 https://doi.org/10.1634/stemcells.2004-0137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048582243
473 rdf:type schema:CreativeWork
474 https://doi.org/10.1634/stemcells.2004-0211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045135667
475 rdf:type schema:CreativeWork
476 https://doi.org/10.1634/stemcells.2004-0279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008652652
477 rdf:type schema:CreativeWork
478 https://doi.org/10.1634/stemcells.2004-0303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012991943
479 rdf:type schema:CreativeWork
480 https://doi.org/10.1634/stemcells.2004-0338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035860884
481 rdf:type schema:CreativeWork
482 https://doi.org/10.1634/stemcells.2004-0347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042641866
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1634/stemcells.2005-0034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024628851
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1634/stemcells.2005-0112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042314581
487 rdf:type schema:CreativeWork
488 https://doi.org/10.1634/stemcells.2005-0247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036210003
489 rdf:type schema:CreativeWork
490 https://doi.org/10.1634/stemcells.2005-0299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039506700
491 rdf:type schema:CreativeWork
492 https://doi.org/10.1634/stemcells.2005-0398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010512439
493 rdf:type schema:CreativeWork
494 https://doi.org/10.1634/stemcells.21-1-111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051806446
495 rdf:type schema:CreativeWork
496 https://doi.org/10.1634/stemcells.21-2-131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014191723
497 rdf:type schema:CreativeWork
498 https://doi.org/10.1634/stemcells.21-3-257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025112128
499 rdf:type schema:CreativeWork
500 https://doi.org/10.1634/stemcells.21-5-546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050445045
501 rdf:type schema:CreativeWork
502 https://doi.org/10.1634/stemcells.22-3-275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038674692
503 rdf:type schema:CreativeWork
504 https://doi.org/10.1634/stemcells.22-4-433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015160843
505 rdf:type schema:CreativeWork
506 https://doi.org/10.1634/stemcells.22-6-972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003528262
507 rdf:type schema:CreativeWork
508 https://doi.org/10.3109/08977199709021517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030296154
509 rdf:type schema:CreativeWork
510 https://www.grid.ac/institutes/grid.423065.6 schema:Organization
 




Preview window. Press ESC to close (or click here)


...