Polynucleotides encoding Notch receptor antibodies


Ontology type: sgo:Patent     


Patent Info

DATE

2015-02-03T00:00

AUTHORS

GURNEY AUSTIN L , HOEY TIMOTHY CHARLES , HTUN VAN DER HORST EDWARD THEIN , SATO AARON KEN , LIU YUAN CHING , BRUHNS MAUREEN FITCH , LEWICKI JOHN A

ABSTRACT

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. More... »

Related SciGraph Publications

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  • 2009-04-09. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia in LEUKEMIA
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
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  • 2005-06-06. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells in ONCOGENE
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  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2007-01-12. Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells in HISTOCHEMISTRY AND CELL BIOLOGY
  • 1995-09. Signalling downstream of activated mammalian Notch in NATURE
  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
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  • 2005-08-23. The Notch pathway in ovarian carcinomas and adenomas in BRITISH JOURNAL OF CANCER
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