Method for identifying, expanding and removing adult stem cells and cancer stem cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Johannes Carolus Clevers , Nicholas Barker , Andrea Haegebarth , Marcus Lambertus Van de Wetering

ABSTRACT

Described are the use of stem cell markers for the isolation of stem cells and the use of the obtained stem cells in, for example, research or treatment, such as for the preparation of a medicament for the treatment of damaged or diseased tissue. In one aspect, provided is a method for obtaining or isolating stem cells that comprises preparing a cell suspension from a tissue or organ sample, contacting the cell suspension with an Lgr 6 or 5 binding compound, identifying the cells bound to the binding compound, and isolating the stem cells from the binding compound. Further described are methods and compositions for cancer treatment, for example, by eradicating cancer stem cells. More... »

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