Screening method using gelatinase-mediated EphA4 cleavage reaction as an indicator


Ontology type: sgo:Patent     


Patent Info

DATE

2014-10-21T00:00

AUTHORS

INOUE EIJI

ABSTRACT

The object of the present invention is to provide a method for screening a substance that affects gelatinase-mediated EphA4 processing. The present invention provides a method for screening a substance that affects gelatinase-mediated EphA4 processing, which comprises the steps of: (a) allowing a first biological composition containing gelatinase or a biologically active fragment thereof to be contacted with a second biological composition containing EphA4 in the presence and absence of a candidate substance; (b) measuring the presence or amount of the EphA4 ectodomain and/or endodomain fragment; and (c) selecting the candidate substance as a substance that affects gelatinase-mediated EphA4 processing if the results of the step (b) measured in the presence of the candidate substance are changed in comparison with the results of the step (b) measured in the absence of the candidate substance. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "INOUE EIJI", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35041577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045506559", 
          "https://doi.org/10.1038/35041577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037079838", 
          "https://doi.org/10.1038/nn994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050863948", 
          "https://doi.org/10.1038/nn1630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005035720", 
          "https://doi.org/10.1038/nrm1406"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10-21T00:00", 
    "description": "

The object of the present invention is to provide a method for screening a substance that affects gelatinase-mediated EphA4 processing. The present invention provides a method for screening a substance that affects gelatinase-mediated EphA4 processing, which comprises the steps of: (a) allowing a first biological composition containing gelatinase or a biologically active fragment thereof to be contacted with a second biological composition containing EphA4 in the presence and absence of a candidate substance; (b) measuring the presence or amount of the EphA4 ectodomain and/or endodomain fragment; and (c) selecting the candidate substance as a substance that affects gelatinase-mediated EphA4 processing if the results of the step (b) measured in the presence of the candidate substance are changed in comparison with the results of the step (b) measured in the absence of the candidate substance.

", "endDate": "2031-12-08", "id": "sg:patent.US-8865426-B2", "name": "Screening method using gelatinase-mediated EphA4 cleavage reaction as an indicator", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.418765.9", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8865426-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_4.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8865426-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8865426-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8865426-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8865426-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

42 TRIPLES      15 PREDICATES      20 URIs      9 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-8865426-B2 schema:about anzsrc-for:17
2 anzsrc-for:1701
3 schema:author Nc286ab8366e24bb39bc0d0a1f8340adf
4 schema:citation sg:pub.10.1038/35041577
5 sg:pub.10.1038/nn1630
6 sg:pub.10.1038/nn994
7 sg:pub.10.1038/nrm1406
8 schema:datePublished 2014-10-21T00:00
9 schema:description <p num="p-0001">The object of the present invention is to provide a method for screening a substance that affects gelatinase-mediated EphA4 processing. The present invention provides a method for screening a substance that affects gelatinase-mediated EphA4 processing, which comprises the steps of: (a) allowing a first biological composition containing gelatinase or a biologically active fragment thereof to be contacted with a second biological composition containing EphA4 in the presence and absence of a candidate substance; (b) measuring the presence or amount of the EphA4 ectodomain and/or endodomain fragment; and (c) selecting the candidate substance as a substance that affects gelatinase-mediated EphA4 processing if the results of the step (b) measured in the presence of the candidate substance are changed in comparison with the results of the step (b) measured in the absence of the candidate substance.</p>
10 schema:endDate 2031-12-08
11 schema:name Screening method using gelatinase-mediated EphA4 cleavage reaction as an indicator
12 schema:recipient grid-institutes:grid.418765.9
13 schema:sameAs https://app.dimensions.ai/details/patent/US-8865426-B2
14 schema:sdDatePublished 2022-09-02T16:21
15 schema:sdLicense https://scigraph.springernature.com/explorer/license/
16 schema:sdPublisher Ne0ac090b92e44ad2bbfd8317061a4a0d
17 sgo:license sg:explorer/license/
18 sgo:sdDataset patents
19 rdf:type sgo:Patent
20 Nb910ca70f67d45d6aa2c24d7d795b319 schema:name INOUE EIJI
21 rdf:type schema:Person
22 Nc286ab8366e24bb39bc0d0a1f8340adf rdf:first Nb910ca70f67d45d6aa2c24d7d795b319
23 rdf:rest rdf:nil
24 Ne0ac090b92e44ad2bbfd8317061a4a0d schema:name Springer Nature - SN SciGraph project
25 rdf:type schema:Organization
26 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
27 rdf:type schema:DefinedTerm
28 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
29 rdf:type schema:DefinedTerm
30 sg:pub.10.1038/35041577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045506559
31 https://doi.org/10.1038/35041577
32 rdf:type schema:CreativeWork
33 sg:pub.10.1038/nn1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050863948
34 https://doi.org/10.1038/nn1630
35 rdf:type schema:CreativeWork
36 sg:pub.10.1038/nn994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037079838
37 https://doi.org/10.1038/nn994
38 rdf:type schema:CreativeWork
39 sg:pub.10.1038/nrm1406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005035720
40 https://doi.org/10.1038/nrm1406
41 rdf:type schema:CreativeWork
42 grid-institutes:grid.418765.9 schema:Organization
 




Preview window. Press ESC to close (or click here)


...