Production of glycoproteins with reduced O-glycosylation


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Piotr Bobrowicz , W. James Cook , Warren Kett

ABSTRACT

A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.

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