Genome editing of a Rosa locus using zinc-finger nucleases


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Xiaoxia Cui , Gregory Davis , Philip D. Gregory , Michael C. Holmes , Edward J. Weinstein

ABSTRACT

Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

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