Reprogramming immortalized B-cells to induced pluripotent stem cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

James Thomson , Deepika Rajesh , Sarah Jane Dickerson , Amanda Mack , Michael Miller

ABSTRACT

Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement. More... »

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