Composition and method for enabling proliferation of pluripotent stem cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Karl Tryggvason , Anna Domogatskaya , Sergey Rodin

ABSTRACT

The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or laminin-5 (laminin-322), or their functional domains, the embryonic stem cells proliferated and maintained their pluripotency. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2995", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Karl Tryggvason", 
        "type": "Person"
      }, 
      {
        "name": "Anna Domogatskaya", 
        "type": "Person"
      }, 
      {
        "name": "Sergey Rodin", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1097-0177(200006)218:2<213::aid-dvdy1>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004903426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2005.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006277627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009583211", 
          "https://doi.org/10.1038/nbt726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(83)90183-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010044484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1001-971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014515248", 
          "https://doi.org/10.1038/nbt1001-971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.matbio.2005.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016490345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(85)90491-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017045705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66473-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019112974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra022296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021861051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023274806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra052131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024056555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-0389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027380489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029326356", 
          "https://doi.org/10.1038/nmeth744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030407065", 
          "https://doi.org/10.1038/nbt1177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2006.03.083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032763074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/336684a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038677733", 
          "https://doi.org/10.1038/336684a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66477-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039888131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.matbio.2005.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040963088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.07.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048549285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.20.14853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049208016"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "description": "

The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or laminin-5 (laminin-322), or their functional domains, the embryonic stem cells proliferated and maintained their pluripotency.

", "id": "sg:patent.US-8722405-B2", "keywords": [ "composition", "method", "proliferation", "pluripotent stem cell", "disclosure", "development", "extracellular matrix", "stem cell", "vitro", "undifferentiated state", "mouse", "human embryonic stem cell", "plate", "laminin", "laminin-5", "functional domain", "embryonic stem cell", "pluripotency" ], "name": "Composition and method for enabling proliferation of pluripotent stem cells", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.451737.3", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8722405-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:36", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_c3e5ed81.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8722405-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8722405-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8722405-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8722405-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

118 TRIPLES      14 PREDICATES      53 URIs      25 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-8722405-B2 schema:about anzsrc-for:2581
2 anzsrc-for:2620
3 anzsrc-for:2995
4 schema:author Na43e80f36c404f19ba7841f72bbdc349
5 schema:citation sg:pub.10.1038/336684a0
6 sg:pub.10.1038/nbt1001-971
7 sg:pub.10.1038/nbt1177
8 sg:pub.10.1038/nbt726
9 sg:pub.10.1038/nmeth744
10 https://doi.org/10.1002/(sici)1097-0177(200006)218:2<213::aid-dvdy1>3.0.co;2-r
11 https://doi.org/10.1016/0012-1606(83)90183-5
12 https://doi.org/10.1016/0012-1606(85)90491-9
13 https://doi.org/10.1016/j.bbrc.2008.07.111
14 https://doi.org/10.1016/j.biocel.2005.12.014
15 https://doi.org/10.1016/j.febslet.2006.03.083
16 https://doi.org/10.1016/j.matbio.2005.05.006
17 https://doi.org/10.1016/j.matbio.2005.10.001
18 https://doi.org/10.1016/s0140-6736(05)66473-2
19 https://doi.org/10.1016/s0140-6736(05)66477-x
20 https://doi.org/10.1056/nejmra022296
21 https://doi.org/10.1056/nejmra052131
22 https://doi.org/10.1074/jbc.275.20.14853
23 https://doi.org/10.1634/stemcells.2005-0605
24 https://doi.org/10.1634/stemcells.2007-0389
25 schema:description <p num="p-0001">The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or laminin-5 (laminin-322), or their functional domains, the embryonic stem cells proliferated and maintained their pluripotency.</p>
26 schema:keywords composition
27 development
28 disclosure
29 embryonic stem cell
30 extracellular matrix
31 functional domain
32 human embryonic stem cell
33 laminin
34 laminin-5
35 method
36 mouse
37 plate
38 pluripotency
39 pluripotent stem cell
40 proliferation
41 stem cell
42 undifferentiated state
43 vitro
44 schema:name Composition and method for enabling proliferation of pluripotent stem cells
45 schema:recipient https://www.grid.ac/institutes/grid.451737.3
46 schema:sameAs https://app.dimensions.ai/details/patent/US-8722405-B2
47 schema:sdDatePublished 2019-03-07T15:36
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher Na25764d0ba9746dd841eefbec9493351
50 sgo:license sg:explorer/license/
51 sgo:sdDataset patents
52 rdf:type sgo:Patent
53 N5e95b5d1b46f4863bae515213de2adc4 rdf:first N6ad467cd80dd4e2ab63cd24e1f0a5d41
54 rdf:rest Nd611b7d662304c68bddc4c68688331de
55 N6ad467cd80dd4e2ab63cd24e1f0a5d41 schema:name Anna Domogatskaya
56 rdf:type schema:Person
57 Na25764d0ba9746dd841eefbec9493351 schema:name Springer Nature - SN SciGraph project
58 rdf:type schema:Organization
59 Na43e80f36c404f19ba7841f72bbdc349 rdf:first Nfba2b803e94c4c22ac32ac29a0a58396
60 rdf:rest N5e95b5d1b46f4863bae515213de2adc4
61 Nad4f3146ed754d0d879942e4d90109c8 schema:name Sergey Rodin
62 rdf:type schema:Person
63 Nd611b7d662304c68bddc4c68688331de rdf:first Nad4f3146ed754d0d879942e4d90109c8
64 rdf:rest rdf:nil
65 Nfba2b803e94c4c22ac32ac29a0a58396 schema:name Karl Tryggvason
66 rdf:type schema:Person
67 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
68 rdf:type schema:DefinedTerm
69 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
70 rdf:type schema:DefinedTerm
71 anzsrc-for:2995 schema:inDefinedTermSet anzsrc-for:
72 rdf:type schema:DefinedTerm
73 sg:pub.10.1038/336684a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038677733
74 https://doi.org/10.1038/336684a0
75 rdf:type schema:CreativeWork
76 sg:pub.10.1038/nbt1001-971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014515248
77 https://doi.org/10.1038/nbt1001-971
78 rdf:type schema:CreativeWork
79 sg:pub.10.1038/nbt1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030407065
80 https://doi.org/10.1038/nbt1177
81 rdf:type schema:CreativeWork
82 sg:pub.10.1038/nbt726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009583211
83 https://doi.org/10.1038/nbt726
84 rdf:type schema:CreativeWork
85 sg:pub.10.1038/nmeth744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029326356
86 https://doi.org/10.1038/nmeth744
87 rdf:type schema:CreativeWork
88 https://doi.org/10.1002/(sici)1097-0177(200006)218:2<213::aid-dvdy1>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1004903426
89 rdf:type schema:CreativeWork
90 https://doi.org/10.1016/0012-1606(83)90183-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010044484
91 rdf:type schema:CreativeWork
92 https://doi.org/10.1016/0012-1606(85)90491-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017045705
93 rdf:type schema:CreativeWork
94 https://doi.org/10.1016/j.bbrc.2008.07.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048549285
95 rdf:type schema:CreativeWork
96 https://doi.org/10.1016/j.biocel.2005.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006277627
97 rdf:type schema:CreativeWork
98 https://doi.org/10.1016/j.febslet.2006.03.083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032763074
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1016/j.matbio.2005.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016490345
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1016/j.matbio.2005.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040963088
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1016/s0140-6736(05)66473-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019112974
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1016/s0140-6736(05)66477-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039888131
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1056/nejmra022296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021861051
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1056/nejmra052131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024056555
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1074/jbc.275.20.14853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049208016
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1634/stemcells.2005-0605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023274806
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1634/stemcells.2007-0389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027380489
117 rdf:type schema:CreativeWork
118 https://www.grid.ac/institutes/grid.451737.3 schema:Organization
 




Preview window. Press ESC to close (or click here)


...