Methods for enhancing hematopoietic progenitor cell engraftment


Ontology type: sgo:Patent     


Patent Info

DATE

2013-10-01T00:00

AUTHORS

Olaia Naveiras , George Daley , Pamela L. Wenzel

ABSTRACT

Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood transplantation). Methods for increasing hematopoietic progenitor cell proliferation in individuals with bone marrow aplasia are also described. The methods involve administering an agent that inhibits adipogenesis, adipocyte growth, adipocyte differentiation and/or adipocyte proliferation. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Olaia Naveiras", 
        "type": "Person"
      }, 
      {
        "name": "George Daley", 
        "type": "Person"
      }, 
      {
        "name": "Pamela L. Wenzel", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1677/joe-08-0050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001388296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.3.1873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002919499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003509222", 
          "https://doi.org/10.1038/nature02040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003509222", 
          "https://doi.org/10.1038/nature02040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.28.6.1536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005685137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.20.3168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007982583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1704400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009500355", 
          "https://doi.org/10.1038/sj.bmt.1704400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1704400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009500355", 
          "https://doi.org/10.1038/sj.bmt.1704400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011517403", 
          "https://doi.org/10.1038/nature08099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011517403", 
          "https://doi.org/10.1038/nature08099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-0007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017587613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033616640", 
          "https://doi.org/10.1038/nature02041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033616640", 
          "https://doi.org/10.1038/nature02041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-06-2159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038659128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2008-0068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040552295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048721879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048721879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(96)00258-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049817469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.261562798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051244772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.12.9.747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083275304"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10-01T00:00", 
    "description": "

Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood transplantation). Methods for increasing hematopoietic progenitor cell proliferation in individuals with bone marrow aplasia are also described. The methods involve administering an agent that inhibits adipogenesis, adipocyte growth, adipocyte differentiation and/or adipocyte proliferation.

", "id": "sg:patent.US-8546382-B2", "keywords": [ "method", "hematopoietic progenitor", "engraftment", "hematopoietic cell", "bone marrow", "cord blood transplantation", "progenitor cell proliferation", "individual", "agent", "adipogenesis", "adipocytes", "adipocyte differentiation", "proliferation" ], "name": "Methods for enhancing hematopoietic progenitor cell engraftment", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.414196.f", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.2515.3", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.414197.e", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8546382-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:11", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00663.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8546382-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8546382-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8546382-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8546382-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

99 TRIPLES      15 PREDICATES      45 URIs      21 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-8546382-B2 schema:about anzsrc-for:2581
2 schema:author Nea94c226c9c9429cb59802a6a077e08c
3 schema:citation sg:pub.10.1038/nature02040
4 sg:pub.10.1038/nature02041
5 sg:pub.10.1038/nature08099
6 sg:pub.10.1038/sj.bmt.1704400
7 https://doi.org/10.1016/j.cell.2005.05.026
8 https://doi.org/10.1016/s8756-3282(96)00258-x
9 https://doi.org/10.1073/pnas.261562798
10 https://doi.org/10.1074/jbc.275.3.1873
11 https://doi.org/10.1096/fasebj.12.9.747
12 https://doi.org/10.1101/gad.12.20.3168
13 https://doi.org/10.1182/blood-2004-06-2159
14 https://doi.org/10.1210/en.2006-1587
15 https://doi.org/10.1634/stemcells.2008-0068
16 https://doi.org/10.1677/joe-08-0050
17 https://doi.org/10.2337/db07-0007
18 https://doi.org/10.2337/diacare.28.6.1536
19 schema:datePublished 2013-10-01T00:00
20 schema:description <p num="p-0001">Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood transplantation). Methods for increasing hematopoietic progenitor cell proliferation in individuals with bone marrow aplasia are also described. The methods involve administering an agent that inhibits adipogenesis, adipocyte growth, adipocyte differentiation and/or adipocyte proliferation.</p>
21 schema:keywords adipocyte differentiation
22 adipocytes
23 adipogenesis
24 agent
25 bone marrow
26 cord blood transplantation
27 engraftment
28 hematopoietic cell
29 hematopoietic progenitor
30 individual
31 method
32 progenitor cell proliferation
33 proliferation
34 schema:name Methods for enhancing hematopoietic progenitor cell engraftment
35 schema:recipient https://www.grid.ac/institutes/grid.2515.3
36 https://www.grid.ac/institutes/grid.414196.f
37 https://www.grid.ac/institutes/grid.414197.e
38 schema:sameAs https://app.dimensions.ai/details/patent/US-8546382-B2
39 schema:sdDatePublished 2019-04-18T10:11
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher N35c18f0a4c0b45f8b9845b847884ccd4
42 sgo:license sg:explorer/license/
43 sgo:sdDataset patents
44 rdf:type sgo:Patent
45 N2e6182899ae74eadb2cfe8e5a3c459ee rdf:first N2f572a0ac6b74c9a878daf48095c29ad
46 rdf:rest Ncf8fc02400c64d1b95f4c9cc3024b1b1
47 N2f572a0ac6b74c9a878daf48095c29ad schema:name George Daley
48 rdf:type schema:Person
49 N35c18f0a4c0b45f8b9845b847884ccd4 schema:name Springer Nature - SN SciGraph project
50 rdf:type schema:Organization
51 N497488cc83ef4bfe8c033eb9758090c2 schema:name Olaia Naveiras
52 rdf:type schema:Person
53 Na06610471fed4df2afdcb6f8e1fcae25 schema:name Pamela L. Wenzel
54 rdf:type schema:Person
55 Ncf8fc02400c64d1b95f4c9cc3024b1b1 rdf:first Na06610471fed4df2afdcb6f8e1fcae25
56 rdf:rest rdf:nil
57 Nea94c226c9c9429cb59802a6a077e08c rdf:first N497488cc83ef4bfe8c033eb9758090c2
58 rdf:rest N2e6182899ae74eadb2cfe8e5a3c459ee
59 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
60 rdf:type schema:DefinedTerm
61 sg:pub.10.1038/nature02040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509222
62 https://doi.org/10.1038/nature02040
63 rdf:type schema:CreativeWork
64 sg:pub.10.1038/nature02041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033616640
65 https://doi.org/10.1038/nature02041
66 rdf:type schema:CreativeWork
67 sg:pub.10.1038/nature08099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011517403
68 https://doi.org/10.1038/nature08099
69 rdf:type schema:CreativeWork
70 sg:pub.10.1038/sj.bmt.1704400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009500355
71 https://doi.org/10.1038/sj.bmt.1704400
72 rdf:type schema:CreativeWork
73 https://doi.org/10.1016/j.cell.2005.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048721879
74 rdf:type schema:CreativeWork
75 https://doi.org/10.1016/s8756-3282(96)00258-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049817469
76 rdf:type schema:CreativeWork
77 https://doi.org/10.1073/pnas.261562798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051244772
78 rdf:type schema:CreativeWork
79 https://doi.org/10.1074/jbc.275.3.1873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002919499
80 rdf:type schema:CreativeWork
81 https://doi.org/10.1096/fasebj.12.9.747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083275304
82 rdf:type schema:CreativeWork
83 https://doi.org/10.1101/gad.12.20.3168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007982583
84 rdf:type schema:CreativeWork
85 https://doi.org/10.1182/blood-2004-06-2159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038659128
86 rdf:type schema:CreativeWork
87 https://doi.org/10.1210/en.2006-1587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248441
88 rdf:type schema:CreativeWork
89 https://doi.org/10.1634/stemcells.2008-0068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040552295
90 rdf:type schema:CreativeWork
91 https://doi.org/10.1677/joe-08-0050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001388296
92 rdf:type schema:CreativeWork
93 https://doi.org/10.2337/db07-0007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017587613
94 rdf:type schema:CreativeWork
95 https://doi.org/10.2337/diacare.28.6.1536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005685137
96 rdf:type schema:CreativeWork
97 https://www.grid.ac/institutes/grid.2515.3 schema:Organization
98 https://www.grid.ac/institutes/grid.414196.f schema:Organization
99 https://www.grid.ac/institutes/grid.414197.e schema:Organization
 




Preview window. Press ESC to close (or click here)


...