Method of screening for compounds which affect the cleavage of EphA7 byγ-secretase


Ontology type: sgo:Patent     


Patent Info

DATE

2013-09-10T00:00

AUTHORS

INOUE EIJI

ABSTRACT

The present invention provides a method of screening for compounds which affect the cleavage of EphA7 by γ-secretase. The method includes the following steps: (i) contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition containing EphA7 in the presence and absence of a candidate compound;(ii) measuring the cleavage of the EphA7 in the presence and absence of the candidate compound;(iii) selecting those candidate compounds which affect the cleavage of the EphA7 by γ-secretase; and(iv) identifying the candidate compounds selected in step (iii) as compounds which affect the cleavage of EphA7 by γ-secretase. More... »

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