Methods and compositions for targeted cleavage and recombination


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Fyodor Urnov , Michael C. Holmes , Jeffrey C. Miller , Carl O. Pabo

ABSTRACT

Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins. More... »

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