ApoIII and the treatment and diagnosis of diabetes


Ontology type: sgo:Patent     


Patent Info

DATE

2013-08-13T00:00

AUTHORS

BERGGREN PER-OLOF

ABSTRACT

The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic β cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic β cells. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "BERGGREN PER-OLOF", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01221634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027195140", 
          "https://doi.org/10.1007/bf01221634"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08-13T00:00", 
    "description": "

The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic β cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic β cells.

", "endDate": "2025-02-05", "id": "sg:patent.US-8507444-B2", "name": "ApoIII and the treatment and diagnosis of diabetes", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.508995.8", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8507444-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-08-04T17:25", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/patent/patent_21.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8507444-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8507444-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8507444-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8507444-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

30 TRIPLES      15 PREDICATES      17 URIs      9 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-8507444-B2 schema:about anzsrc-for:11
2 anzsrc-for:1116
3 schema:author N3b22f5db8a0b4135b152f6bef906f6c8
4 schema:citation sg:pub.10.1007/bf01221634
5 schema:datePublished 2013-08-13T00:00
6 schema:description <p num="p-0001">The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic &#946; cells with an amount of apolipoprotein CIII (&#8220;apoCIII&#8221;) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic &#946; cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic &#946; cells.</p>
7 schema:endDate 2025-02-05
8 schema:name ApoIII and the treatment and diagnosis of diabetes
9 schema:recipient grid-institutes:grid.508995.8
10 schema:sameAs https://app.dimensions.ai/details/patent/US-8507444-B2
11 schema:sdDatePublished 2022-08-04T17:25
12 schema:sdLicense https://scigraph.springernature.com/explorer/license/
13 schema:sdPublisher N9ac3976634084ae699bb0341ba3291f0
14 sgo:license sg:explorer/license/
15 sgo:sdDataset patents
16 rdf:type sgo:Patent
17 N0f0c5f9b69e94016837c1936e09997ce schema:name BERGGREN PER-OLOF
18 rdf:type schema:Person
19 N3b22f5db8a0b4135b152f6bef906f6c8 rdf:first N0f0c5f9b69e94016837c1936e09997ce
20 rdf:rest rdf:nil
21 N9ac3976634084ae699bb0341ba3291f0 schema:name Springer Nature - SN SciGraph project
22 rdf:type schema:Organization
23 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
24 rdf:type schema:DefinedTerm
25 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
26 rdf:type schema:DefinedTerm
27 sg:pub.10.1007/bf01221634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027195140
28 https://doi.org/10.1007/bf01221634
29 rdf:type schema:CreativeWork
30 grid-institutes:grid.508995.8 schema:Organization
 




Preview window. Press ESC to close (or click here)


...