Human beta-glucuronidase mutants with elevated enzymatic activity under physiological conditions and method for identifying such


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Steve Roffler , Chia-Hung Wu , Wolfgang Schechinger , Kai-Chuan Chen , Zeljko Prijovic

ABSTRACT

A number of human beta-glucuronidase variants having higher enzymatic activity at physiological pH as compared with wild-type beta-glucuronidase and uses thereof in prodrug therapy. Also disclosed herein is a method for identifying enzyme variants having elevated enzymatic activity using a mammalian surface display system.

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