Methods of using antibodies that bind the glutamate ligand binding region of Notch1


Ontology type: sgo:Patent     


Patent Info

DATE

2013-06-11T00:00

AUTHORS

GURNEY AUSTIN , SATO AARON , FITCH-BRUHNS MAUREEN

ABSTRACT

Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.

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  • 2006-04-13. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia in NATURE REVIEWS CANCER
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