Antibodies to the NOTCH1 receptor


Ontology type: sgo:Patent     


Patent Info

DATE

2013-03-26T00:00

AUTHORS

LEWICKI JOHN A , GURNEY AUSTIN , HOEY TIMOTHY , YEN WAN-CHING , SATYAL SANJEEV

ABSTRACT

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells. More... »

Related SciGraph Publications

  • 2000-06-29. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays in ONCOGENE
  • 2006-04-13. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia in NATURE REVIEWS CANCER
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2007-01-12. Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells in HISTOCHEMISTRY AND CELL BIOLOGY
  • 2005-06. Notch signals control the fate of immature progenitor cells in the intestine in NATURE
  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 1995-09. Signalling downstream of activated mammalian Notch in NATURE
  • 2005-06-12. Notch signaling controls the generation and differentiation of early T lineage progenitors in NATURE IMMUNOLOGY
  • 2005-06-06. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells in ONCOGENE
  • 2005-06. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells in NATURE
  • 2007-02-14. Vessel guidance in NATURE
  • 2000-01-13. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines in ONCOGENE
  • 1999-10. Defining epitopes: It's not as easy as it seems in NATURE BIOTECHNOLOGY
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
  • 2005-08-23. The Notch pathway in ovarian carcinomas and adenomas in BRITISH JOURNAL OF CANCER
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/32", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/31", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3211", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3101", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "LEWICKI JOHN A", 
            "type": "Person"
          }, 
          {
            "name": "GURNEY AUSTIN", 
            "type": "Person"
          }, 
          {
            "name": "HOEY TIMOTHY", 
            "type": "Person"
          }, 
          {
            "name": "YEN WAN-CHING", 
            "type": "Person"
          }, 
          {
            "name": "SATYAL SANJEEV", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ni1216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043382175", 
              "https://doi.org/10.1038/ni1216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013090465", 
              "https://doi.org/10.1038/nm754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046707660", 
              "https://doi.org/10.1038/nature03659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377355a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019765251", 
              "https://doi.org/10.1038/377355a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/445722a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002673152", 
              "https://doi.org/10.1038/445722a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383707a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043218935", 
              "https://doi.org/10.1038/383707a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046925751", 
              "https://doi.org/10.1038/sj.bjc.6602719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050959167", 
              "https://doi.org/10.1038/nrc1880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015449829", 
              "https://doi.org/10.1038/nature03589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367645a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028822583", 
              "https://doi.org/10.1038/367645a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029200703", 
              "https://doi.org/10.1038/sj.onc.1203703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012634585", 
              "https://doi.org/10.1038/sj.onc.1208783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053478064", 
              "https://doi.org/10.1038/sj.onc.1203295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/81390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039701921", 
              "https://doi.org/10.1038/81390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043526173", 
              "https://doi.org/10.1038/13590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424763", 
              "https://doi.org/10.1038/ni1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35102167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021100179", 
              "https://doi.org/10.1038/35102167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-006-0260-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015583094", 
              "https://doi.org/10.1007/s00418-006-0260-8"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-03-26T00:00", 
        "description": "

    The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.

    ", "endDate": "2027-05-31", "id": "sg:patent.US-8404237-B2", "name": "Antibodies to the NOTCH1 receptor", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.467496.e", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8404237-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-11-24T21:23", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/patent/patent_46.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8404237-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8404237-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8404237-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8404237-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    120 TRIPLES      15 PREDICATES      36 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-8404237-B2 schema:about anzsrc-for:31
    2 anzsrc-for:3101
    3 anzsrc-for:32
    4 anzsrc-for:3211
    5 schema:author N1d41ce42f0c64ddcaca3739329da456e
    6 schema:citation sg:pub.10.1007/s00418-006-0260-8
    7 sg:pub.10.1038/13590
    8 sg:pub.10.1038/35102167
    9 sg:pub.10.1038/367645a0
    10 sg:pub.10.1038/377355a0
    11 sg:pub.10.1038/383707a0
    12 sg:pub.10.1038/445722a
    13 sg:pub.10.1038/81390
    14 sg:pub.10.1038/nature03589
    15 sg:pub.10.1038/nature03659
    16 sg:pub.10.1038/ni1164
    17 sg:pub.10.1038/ni1216
    18 sg:pub.10.1038/nm754
    19 sg:pub.10.1038/nrc1880
    20 sg:pub.10.1038/sj.bjc.6602719
    21 sg:pub.10.1038/sj.onc.1203295
    22 sg:pub.10.1038/sj.onc.1203703
    23 sg:pub.10.1038/sj.onc.1208783
    24 schema:datePublished 2013-03-26T00:00
    25 schema:description <p num="p-0001">The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.</p>
    26 schema:endDate 2027-05-31
    27 schema:name Antibodies to the NOTCH1 receptor
    28 schema:recipient grid-institutes:grid.467496.e
    29 schema:sameAs https://app.dimensions.ai/details/patent/US-8404237-B2
    30 schema:sdDatePublished 2022-11-24T21:23
    31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    32 schema:sdPublisher N40862f9ec8f241f198fe7b0b13b97c52
    33 sgo:license sg:explorer/license/
    34 sgo:sdDataset patents
    35 rdf:type sgo:Patent
    36 N12e3103182e94d4c9b6b2a39125670cf schema:name GURNEY AUSTIN
    37 rdf:type schema:Person
    38 N1d0e2a2aaf8e4862bf1fcba18993a81b schema:name SATYAL SANJEEV
    39 rdf:type schema:Person
    40 N1d41ce42f0c64ddcaca3739329da456e rdf:first Ne0f1383fff0d463ab8a729326556cd2f
    41 rdf:rest N36e00dd234124a3682f0fa908548d4fc
    42 N2921b389a6ba4138b02cf8efc20d995c rdf:first Ne6588d3716bf4a5aa9fac9589e7bc00c
    43 rdf:rest N4d0238c2b67841308439ab66569aed65
    44 N2d4abc4d0b2d46fcbd189afee08837d0 rdf:first N1d0e2a2aaf8e4862bf1fcba18993a81b
    45 rdf:rest rdf:nil
    46 N327649e90a9947cb982967598fd224d1 schema:name YEN WAN-CHING
    47 rdf:type schema:Person
    48 N36e00dd234124a3682f0fa908548d4fc rdf:first N12e3103182e94d4c9b6b2a39125670cf
    49 rdf:rest N2921b389a6ba4138b02cf8efc20d995c
    50 N40862f9ec8f241f198fe7b0b13b97c52 schema:name Springer Nature - SN SciGraph project
    51 rdf:type schema:Organization
    52 N4d0238c2b67841308439ab66569aed65 rdf:first N327649e90a9947cb982967598fd224d1
    53 rdf:rest N2d4abc4d0b2d46fcbd189afee08837d0
    54 Ne0f1383fff0d463ab8a729326556cd2f schema:name LEWICKI JOHN A
    55 rdf:type schema:Person
    56 Ne6588d3716bf4a5aa9fac9589e7bc00c schema:name HOEY TIMOTHY
    57 rdf:type schema:Person
    58 anzsrc-for:31 schema:inDefinedTermSet anzsrc-for:
    59 rdf:type schema:DefinedTerm
    60 anzsrc-for:3101 schema:inDefinedTermSet anzsrc-for:
    61 rdf:type schema:DefinedTerm
    62 anzsrc-for:32 schema:inDefinedTermSet anzsrc-for:
    63 rdf:type schema:DefinedTerm
    64 anzsrc-for:3211 schema:inDefinedTermSet anzsrc-for:
    65 rdf:type schema:DefinedTerm
    66 sg:pub.10.1007/s00418-006-0260-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015583094
    67 https://doi.org/10.1007/s00418-006-0260-8
    68 rdf:type schema:CreativeWork
    69 sg:pub.10.1038/13590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043526173
    70 https://doi.org/10.1038/13590
    71 rdf:type schema:CreativeWork
    72 sg:pub.10.1038/35102167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100179
    73 https://doi.org/10.1038/35102167
    74 rdf:type schema:CreativeWork
    75 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
    76 https://doi.org/10.1038/367645a0
    77 rdf:type schema:CreativeWork
    78 sg:pub.10.1038/377355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019765251
    79 https://doi.org/10.1038/377355a0
    80 rdf:type schema:CreativeWork
    81 sg:pub.10.1038/383707a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043218935
    82 https://doi.org/10.1038/383707a0
    83 rdf:type schema:CreativeWork
    84 sg:pub.10.1038/445722a schema:sameAs https://app.dimensions.ai/details/publication/pub.1002673152
    85 https://doi.org/10.1038/445722a
    86 rdf:type schema:CreativeWork
    87 sg:pub.10.1038/81390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039701921
    88 https://doi.org/10.1038/81390
    89 rdf:type schema:CreativeWork
    90 sg:pub.10.1038/nature03589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015449829
    91 https://doi.org/10.1038/nature03589
    92 rdf:type schema:CreativeWork
    93 sg:pub.10.1038/nature03659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707660
    94 https://doi.org/10.1038/nature03659
    95 rdf:type schema:CreativeWork
    96 sg:pub.10.1038/ni1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424763
    97 https://doi.org/10.1038/ni1164
    98 rdf:type schema:CreativeWork
    99 sg:pub.10.1038/ni1216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043382175
    100 https://doi.org/10.1038/ni1216
    101 rdf:type schema:CreativeWork
    102 sg:pub.10.1038/nm754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013090465
    103 https://doi.org/10.1038/nm754
    104 rdf:type schema:CreativeWork
    105 sg:pub.10.1038/nrc1880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050959167
    106 https://doi.org/10.1038/nrc1880
    107 rdf:type schema:CreativeWork
    108 sg:pub.10.1038/sj.bjc.6602719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046925751
    109 https://doi.org/10.1038/sj.bjc.6602719
    110 rdf:type schema:CreativeWork
    111 sg:pub.10.1038/sj.onc.1203295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053478064
    112 https://doi.org/10.1038/sj.onc.1203295
    113 rdf:type schema:CreativeWork
    114 sg:pub.10.1038/sj.onc.1203703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029200703
    115 https://doi.org/10.1038/sj.onc.1203703
    116 rdf:type schema:CreativeWork
    117 sg:pub.10.1038/sj.onc.1208783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012634585
    118 https://doi.org/10.1038/sj.onc.1208783
    119 rdf:type schema:CreativeWork
    120 grid-institutes:grid.467496.e schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...