Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease ...


Ontology type: sgo:Patent     


Patent Info

DATE

2013-03-19T00:00

AUTHORS

HELLERSTEIN MARC K

ABSTRACT

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest. More... »

Related SciGraph Publications

  • 1995-07. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection in NATURE MEDICINE
  • 1999-01. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans in NATURE MEDICINE
  • 2007-08-01. Quantitative mass spectrometry in proteomics: a critical review in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 1995-01. Viral dynamics in human immunodeficiency virus type 1 infection in NATURE
  • 1995-07. T-cell dynamics of immunodeficiency in NATURE MEDICINE
  • 1998-02. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy in NATURE MEDICINE
  • 2004-02-01. From monoamines to genomic targets: a paradigm shift for drug discovery in depression in NATURE REVIEWS DRUG DISCOVERY
  • 2000-06. Effects of defibrotide on aorta and brain malondialdehyde and antioxidants in cholesterol-induced atherosclerotic rabbits in INTERNATIONAL JOURNAL OF CLINICAL AND LABORATORY RESEARCH
  • 1992-11. Lifespan of human lymphocyte subsets defined by CD45 isoforms in NATURE
  • 2000-01-01. Proteome analysis using selective incorporation of isotopically labeled amino acids in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 2001-05. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue in BREAST CANCER RESEARCH AND TREATMENT
  • 1995-01. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection in NATURE
  • 1995-05. CD4+ cell turnover in NATURE
  • 2000-07-25. De novo lipogenesis in adipose tissue of lean and obese women: application of deuterated water and isotope ratio mass spectrometry in INTERNATIONAL JOURNAL OF OBESITY
  • 1997-05. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies in NATURE MEDICINE
  • 1999-05-01. Molecular ion fragmentation and its effects on mass isotopomer abundances of fatty acid methyl esters ionized by electron impact in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 2001-06-01. Elimination of the concentration dependence in mass isotopomer abundance mass spectrometry of methyl palmitate using metastable atom bombardment in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 1995-09. Role of apoptosis in HIV disease pathogenesis in JOURNAL OF CLINICAL IMMUNOLOGY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "HELLERSTEIN MARC K", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/4772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051733099", 
              "https://doi.org/10.1038/4772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1044-0305(99)00003-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020130566", 
              "https://doi.org/10.1016/s1044-0305(99)00003-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0298-215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040912634", 
              "https://doi.org/10.1038/nm0298-215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003179281", 
              "https://doi.org/10.1038/nrd1303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-007-1486-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001825252", 
              "https://doi.org/10.1007/s00216-007-1486-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1044-0305(99)00120-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003136388", 
              "https://doi.org/10.1016/s1044-0305(99)00120-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373123a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014949926", 
              "https://doi.org/10.1038/373123a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1044-0305(01)00227-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053222022", 
              "https://doi.org/10.1016/s1044-0305(01)00227-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0795-621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050391753", 
              "https://doi.org/10.1038/nm0795-621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s005990070022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029702387", 
              "https://doi.org/10.1007/s005990070022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0795-674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000284466", 
              "https://doi.org/10.1038/nm0795-674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373117a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025418642", 
              "https://doi.org/10.1038/373117a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1010615124301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013545902", 
              "https://doi.org/10.1023/a:1010615124301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/375193b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018438812", 
              "https://doi.org/10.1038/375193b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01540879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022605986", 
              "https://doi.org/10.1007/bf01540879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/360264a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017658165", 
              "https://doi.org/10.1038/360264a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0597-533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002856145", 
              "https://doi.org/10.1038/nm0597-533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0801256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027399842", 
              "https://doi.org/10.1038/sj.ijo.0801256"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-03-19T00:00", 
        "description": "

    The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest.

    ", "endDate": "2025-02-22", "id": "sg:patent.US-8401800-B2", "name": "Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.30389.31", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8401800-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-10-01T07:03", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/patent/patent_21.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8401800-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8401800-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8401800-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8401800-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    98 TRIPLES      15 PREDICATES      34 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-8401800-B2 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Nd3601f5169f3420d97895744ae490418
    4 schema:citation sg:pub.10.1007/bf01540879
    5 sg:pub.10.1007/s00216-007-1486-6
    6 sg:pub.10.1007/s005990070022
    7 sg:pub.10.1016/s1044-0305(01)00227-6
    8 sg:pub.10.1016/s1044-0305(99)00003-3
    9 sg:pub.10.1016/s1044-0305(99)00120-8
    10 sg:pub.10.1023/a:1010615124301
    11 sg:pub.10.1038/360264a0
    12 sg:pub.10.1038/373117a0
    13 sg:pub.10.1038/373123a0
    14 sg:pub.10.1038/375193b0
    15 sg:pub.10.1038/4772
    16 sg:pub.10.1038/nm0298-215
    17 sg:pub.10.1038/nm0597-533
    18 sg:pub.10.1038/nm0795-621
    19 sg:pub.10.1038/nm0795-674
    20 sg:pub.10.1038/nrd1303
    21 sg:pub.10.1038/sj.ijo.0801256
    22 schema:datePublished 2013-03-19T00:00
    23 schema:description <p num="p-0001">The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest.</p>
    24 schema:endDate 2025-02-22
    25 schema:name Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
    26 schema:recipient grid-institutes:grid.30389.31
    27 schema:sameAs https://app.dimensions.ai/details/patent/US-8401800-B2
    28 schema:sdDatePublished 2022-10-01T07:03
    29 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    30 schema:sdPublisher Na8d9db1cdee74eef85ab607bb9c60a15
    31 sgo:license sg:explorer/license/
    32 sgo:sdDataset patents
    33 rdf:type sgo:Patent
    34 N6538381b7d494051a10960b1c29771ac schema:name HELLERSTEIN MARC K
    35 rdf:type schema:Person
    36 Na8d9db1cdee74eef85ab607bb9c60a15 schema:name Springer Nature - SN SciGraph project
    37 rdf:type schema:Organization
    38 Nd3601f5169f3420d97895744ae490418 rdf:first N6538381b7d494051a10960b1c29771ac
    39 rdf:rest rdf:nil
    40 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    41 rdf:type schema:DefinedTerm
    42 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    43 rdf:type schema:DefinedTerm
    44 sg:pub.10.1007/bf01540879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022605986
    45 https://doi.org/10.1007/bf01540879
    46 rdf:type schema:CreativeWork
    47 sg:pub.10.1007/s00216-007-1486-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001825252
    48 https://doi.org/10.1007/s00216-007-1486-6
    49 rdf:type schema:CreativeWork
    50 sg:pub.10.1007/s005990070022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029702387
    51 https://doi.org/10.1007/s005990070022
    52 rdf:type schema:CreativeWork
    53 sg:pub.10.1016/s1044-0305(01)00227-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053222022
    54 https://doi.org/10.1016/s1044-0305(01)00227-6
    55 rdf:type schema:CreativeWork
    56 sg:pub.10.1016/s1044-0305(99)00003-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020130566
    57 https://doi.org/10.1016/s1044-0305(99)00003-3
    58 rdf:type schema:CreativeWork
    59 sg:pub.10.1016/s1044-0305(99)00120-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003136388
    60 https://doi.org/10.1016/s1044-0305(99)00120-8
    61 rdf:type schema:CreativeWork
    62 sg:pub.10.1023/a:1010615124301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013545902
    63 https://doi.org/10.1023/a:1010615124301
    64 rdf:type schema:CreativeWork
    65 sg:pub.10.1038/360264a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017658165
    66 https://doi.org/10.1038/360264a0
    67 rdf:type schema:CreativeWork
    68 sg:pub.10.1038/373117a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025418642
    69 https://doi.org/10.1038/373117a0
    70 rdf:type schema:CreativeWork
    71 sg:pub.10.1038/373123a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014949926
    72 https://doi.org/10.1038/373123a0
    73 rdf:type schema:CreativeWork
    74 sg:pub.10.1038/375193b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018438812
    75 https://doi.org/10.1038/375193b0
    76 rdf:type schema:CreativeWork
    77 sg:pub.10.1038/4772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051733099
    78 https://doi.org/10.1038/4772
    79 rdf:type schema:CreativeWork
    80 sg:pub.10.1038/nm0298-215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040912634
    81 https://doi.org/10.1038/nm0298-215
    82 rdf:type schema:CreativeWork
    83 sg:pub.10.1038/nm0597-533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002856145
    84 https://doi.org/10.1038/nm0597-533
    85 rdf:type schema:CreativeWork
    86 sg:pub.10.1038/nm0795-621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050391753
    87 https://doi.org/10.1038/nm0795-621
    88 rdf:type schema:CreativeWork
    89 sg:pub.10.1038/nm0795-674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000284466
    90 https://doi.org/10.1038/nm0795-674
    91 rdf:type schema:CreativeWork
    92 sg:pub.10.1038/nrd1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003179281
    93 https://doi.org/10.1038/nrd1303
    94 rdf:type schema:CreativeWork
    95 sg:pub.10.1038/sj.ijo.0801256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027399842
    96 https://doi.org/10.1038/sj.ijo.0801256
    97 rdf:type schema:CreativeWork
    98 grid-institutes:grid.30389.31 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...