Genetic control of mammalian cells with synthetic RNA regulatory systems


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Christina D. Smolke , YVONNE Y. CHEN , Michael C. Jensen

ABSTRACT

The present application relates to nucleic acids that encode a RNA switch responsive to a ligand that can control the expression of a gene product that affects the cell fate determination of a mammalian cell are provided. In some embodiments, the system can be used to control the proliferation or activation of mammalian cells in response to a ligand that can be provided exogenously to the mammalian cell or can be produced by the mammalian cell. The system can be used to promote the growth or proliferation of human T cells in response to an exogenous ligand applied to the cells. In one embodiment, the system detects the ligand through a RNA aptamer that modulates expression of a gene product through activation or inactivation of a ribozyme that modulates expression of the gene product. More... »

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    The present application relates to nucleic acids that encode a RNA switch responsive to a ligand that can control the expression of a gene product that affects the cell fate determination of a mammalian cell are provided. In some embodiments, the system can be used to control the proliferation or activation of mammalian cells in response to a ligand that can be provided exogenously to the mammalian cell or can be produced by the mammalian cell. The system can be used to promote the growth or proliferation of human T cells in response to an exogenous ligand applied to the cells. In one embodiment, the system detects the ligand through a RNA aptamer that modulates expression of a gene product through activation or inactivation of a ribozyme that modulates expression of the gene product.

    ", "id": "sg:patent.US-8329882-B2", "keywords": [ "genetic control", "mammalian cell", "regulatory system", "present application", "nucleic acid", "switch", "ligand", "control", "expression", "gene product", "cell fate determination", "embodiment", "proliferation", "human T cell", "exogenous ligand", "cell", "RNA aptamer", "inactivation", "ribozyme" ], "name": "Genetic control of mammalian cells with synthetic RNA regulatory systems", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.410425.6", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.20861.3d", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8329882-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:35", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_b65d5aab.jsonl", "type": "Patent" } ]
     

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