Antibodies to notch receptors


Ontology type: sgo:Patent     


Patent Info

DATE

2012-07-24T00:00

AUTHORS

GURNEY AUSTIN L , HOEY TIMOTHY CHARLES , VAN DER HORST EDWARD THEIN HTUN , SATO AARON KEN , LIU YUAN CHING , BRUHNS MAUREEN FITCH , LEWICKI JOHN A

ABSTRACT

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. More... »

Related SciGraph Publications

  • 2000-06-29. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays in ONCOGENE
  • 2006-04-13. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia in NATURE REVIEWS CANCER
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2005-06. Notch signals control the fate of immature progenitor cells in the intestine in NATURE
  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2005-06-12. Notch signaling controls the generation and differentiation of early T lineage progenitors in NATURE IMMUNOLOGY
  • 2005-06-06. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells in ONCOGENE
  • 2005-06. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells in NATURE
  • 2007-02-14. Vessel guidance in NATURE
  • 2000-01-13. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines in ONCOGENE
  • 1995-09. Signalling downstream of activated mammalian Notch in NATURE
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
  • 2005-08-23. The Notch pathway in ovarian carcinomas and adenomas in BRITISH JOURNAL OF CANCER
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
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