Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Hina W. Chaudhry , Debra J. Wolgemuth

ABSTRACT

The present invention provides methods for promoting generation of heart tissue, and for treating and preventing heart tissue degeneration. Additionally, the present invention provides a therapeutic composition comprising a cyclin-associated agent, and a kit comprising the composition. The present invention further provides a heart tissue cell, a sidepopulation progenitor cell, and a stem cell in which cyclin is augmented. Also provided are cell lines comprising these cells, screening methods using the cell lines, and drugs identified by these methods. The present invention further provides in vitro systems for use in screening candidate drugs for at least one cardiotoxic effect and/or for synergy with cyclin in the treatment and prevention of heart tissue degeneration. Finally, the present invention provides use of a cyclin-associated agent in the generation of heart tissue, and use of a cyclin associated agent in the treatment or prevention of heart tissue degeneration. More... »

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