Artificial base pairs and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2012-07-03T00:00

AUTHORS

Ichiro Hirao , Michiko Hirao , Shigeyuki Yokoyama

ABSTRACT

The present invention provides nucleic acids based on novel artificial base pairing, as well as a preparation method and uses thereof.In the nucleic acids of the present invention, a nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group as a base forms a base pair with a nucleotide having a 6-substituted 9H-purin-9-yl group as a base. The inventive method for preparing a nucleic acid comprises effecting transcription, reverse transcription or replication by using, as a template, a nucleic acid incorporating a nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group as a base, so that the nucleotide having a 6-substituted 9H-purin-9-yl group is incorporated at a site complementary to the nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Ichiro Hirao", 
        "type": "Person"
      }, 
      {
        "name": "Michiko Hirao", 
        "type": "Person"
      }, 
      {
        "name": "Shigeyuki Yokoyama", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1021/ja0425280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000291051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0425280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000291051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.19.11605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002392321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nass/44.1.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006012240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b108185n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013683468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2004.07.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016078501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-894x(01)00415-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017809766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00120-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020397764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00120-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020397764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nass/2.1.219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021922051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/343033a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023013667", 
          "https://doi.org/10.1038/343033a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2003.09.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023356015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.73.012803.092429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026044021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/2925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032653737", 
          "https://doi.org/10.1038/2925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja9925150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035101627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036333083", 
          "https://doi.org/10.1038/19999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.091532698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037098900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nass/1.1.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037575724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/356537a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042018906", 
          "https://doi.org/10.1038/356537a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0202-177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043282175", 
          "https://doi.org/10.1038/nbt0202-177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0202-177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043282175", 
          "https://doi.org/10.1038/nbt0202-177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.3950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043415528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biophys.30.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045805391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00090a027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055160487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9614545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055212387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9614545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055212387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00064a007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055703524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0009931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055706798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0009931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055706798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja028806h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055831850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja028806h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055831850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja047201d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055837227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja047201d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055837227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo00264a024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055976139"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-07-03T00:00", 
    "description": "

The present invention provides nucleic acids based on novel artificial base pairing, as well as a preparation method and uses thereof.

In the nucleic acids of the present invention, a nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group as a base forms a base pair with a nucleotide having a 6-substituted 9H-purin-9-yl group as a base. The inventive method for preparing a nucleic acid comprises effecting transcription, reverse transcription or replication by using, as a template, a nucleic acid incorporating a nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group as a base, so that the nucleotide having a 6-substituted 9H-purin-9-yl group is incorporated at a site complementary to the nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group.

", "id": "sg:patent.US-8212014-B2", "keywords": [ "base-pairs", "invention", "nucleic acid", "Base Pairing", "preparation method", "nucleotide", "base", "method", "transcription", "reverse transcription", "replication", "template" ], "name": "Artificial base pairs and uses thereof", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.7597.c", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.410828.7", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8212014-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:09", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00362.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8212014-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8212014-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8212014-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8212014-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

130 TRIPLES      15 PREDICATES      54 URIs      20 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-8212014-B2 schema:about anzsrc-for:3114
2 schema:author Nc918bc3f821f42a980e12d653b2174e4
3 schema:citation sg:pub.10.1038/19999
4 sg:pub.10.1038/2925
5 sg:pub.10.1038/343033a0
6 sg:pub.10.1038/356537a0
7 sg:pub.10.1038/nbt0202-177
8 https://doi.org/10.1006/jmbi.2000.3950
9 https://doi.org/10.1016/j.bmcl.2003.09.059
10 https://doi.org/10.1016/j.bmcl.2004.07.038
11 https://doi.org/10.1016/s0092-8674(04)00120-5
12 https://doi.org/10.1016/s0960-894x(01)00415-2
13 https://doi.org/10.1021/bi00090a027
14 https://doi.org/10.1021/bi9614545
15 https://doi.org/10.1021/ja00064a007
16 https://doi.org/10.1021/ja0009931
17 https://doi.org/10.1021/ja028806h
18 https://doi.org/10.1021/ja0425280
19 https://doi.org/10.1021/ja047201d
20 https://doi.org/10.1021/ja9925150
21 https://doi.org/10.1021/jo00264a024
22 https://doi.org/10.1039/b108185n
23 https://doi.org/10.1073/pnas.091532698
24 https://doi.org/10.1074/jbc.273.19.11605
25 https://doi.org/10.1093/nass/1.1.17
26 https://doi.org/10.1093/nass/2.1.219
27 https://doi.org/10.1093/nass/44.1.43
28 https://doi.org/10.1146/annurev.biochem.73.012803.092429
29 https://doi.org/10.1146/annurev.biophys.30.1.1
30 schema:datePublished 2012-07-03T00:00
31 schema:description <p num="p-0001">The present invention provides nucleic acids based on novel artificial base pairing, as well as a preparation method and uses thereof.</p><p num="p-0002">In the nucleic acids of the present invention, a nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group as a base forms a base pair with a nucleotide having a 6-substituted 9H-purin-9-yl group as a base. The inventive method for preparing a nucleic acid comprises effecting transcription, reverse transcription or replication by using, as a template, a nucleic acid incorporating a nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group as a base, so that the nucleotide having a 6-substituted 9H-purin-9-yl group is incorporated at a site complementary to the nucleotide having a substituted or unsubstituted 2-formyl-1H-pyrrol-1-yl group.</p>
32 schema:keywords Base Pairing
33 base
34 base-pairs
35 invention
36 method
37 nucleic acid
38 nucleotide
39 preparation method
40 replication
41 reverse transcription
42 template
43 transcription
44 schema:name Artificial base pairs and uses thereof
45 schema:recipient https://www.grid.ac/institutes/grid.410828.7
46 https://www.grid.ac/institutes/grid.7597.c
47 schema:sameAs https://app.dimensions.ai/details/patent/US-8212014-B2
48 schema:sdDatePublished 2019-04-18T10:09
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N952b771716cb49c4ba04ba4425bcf0d9
51 sgo:license sg:explorer/license/
52 sgo:sdDataset patents
53 rdf:type sgo:Patent
54 N26c4bb1aed824d2cbc5e1ddbce0e0a26 schema:name Michiko Hirao
55 rdf:type schema:Person
56 N47b6377b38fb4be69cab1ebad8ccbc8e rdf:first Nc962389d7aaf4f508752841a82fbf94b
57 rdf:rest rdf:nil
58 N6fbb5d16c6614652b2e1ac79033d0169 schema:name Ichiro Hirao
59 rdf:type schema:Person
60 N8b4fd724aa3946f79ce51b7c3ce7437b rdf:first N26c4bb1aed824d2cbc5e1ddbce0e0a26
61 rdf:rest N47b6377b38fb4be69cab1ebad8ccbc8e
62 N952b771716cb49c4ba04ba4425bcf0d9 schema:name Springer Nature - SN SciGraph project
63 rdf:type schema:Organization
64 Nc918bc3f821f42a980e12d653b2174e4 rdf:first N6fbb5d16c6614652b2e1ac79033d0169
65 rdf:rest N8b4fd724aa3946f79ce51b7c3ce7437b
66 Nc962389d7aaf4f508752841a82fbf94b schema:name Shigeyuki Yokoyama
67 rdf:type schema:Person
68 anzsrc-for:3114 schema:inDefinedTermSet anzsrc-for:
69 rdf:type schema:DefinedTerm
70 sg:pub.10.1038/19999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036333083
71 https://doi.org/10.1038/19999
72 rdf:type schema:CreativeWork
73 sg:pub.10.1038/2925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032653737
74 https://doi.org/10.1038/2925
75 rdf:type schema:CreativeWork
76 sg:pub.10.1038/343033a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023013667
77 https://doi.org/10.1038/343033a0
78 rdf:type schema:CreativeWork
79 sg:pub.10.1038/356537a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042018906
80 https://doi.org/10.1038/356537a0
81 rdf:type schema:CreativeWork
82 sg:pub.10.1038/nbt0202-177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043282175
83 https://doi.org/10.1038/nbt0202-177
84 rdf:type schema:CreativeWork
85 https://doi.org/10.1006/jmbi.2000.3950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043415528
86 rdf:type schema:CreativeWork
87 https://doi.org/10.1016/j.bmcl.2003.09.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023356015
88 rdf:type schema:CreativeWork
89 https://doi.org/10.1016/j.bmcl.2004.07.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016078501
90 rdf:type schema:CreativeWork
91 https://doi.org/10.1016/s0092-8674(04)00120-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020397764
92 rdf:type schema:CreativeWork
93 https://doi.org/10.1016/s0960-894x(01)00415-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017809766
94 rdf:type schema:CreativeWork
95 https://doi.org/10.1021/bi00090a027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055160487
96 rdf:type schema:CreativeWork
97 https://doi.org/10.1021/bi9614545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055212387
98 rdf:type schema:CreativeWork
99 https://doi.org/10.1021/ja00064a007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055703524
100 rdf:type schema:CreativeWork
101 https://doi.org/10.1021/ja0009931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055706798
102 rdf:type schema:CreativeWork
103 https://doi.org/10.1021/ja028806h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055831850
104 rdf:type schema:CreativeWork
105 https://doi.org/10.1021/ja0425280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000291051
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1021/ja047201d schema:sameAs https://app.dimensions.ai/details/publication/pub.1055837227
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1021/ja9925150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035101627
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1021/jo00264a024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055976139
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1039/b108185n schema:sameAs https://app.dimensions.ai/details/publication/pub.1013683468
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1073/pnas.091532698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037098900
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1074/jbc.273.19.11605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002392321
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1093/nass/1.1.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037575724
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1093/nass/2.1.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021922051
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1093/nass/44.1.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006012240
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1146/annurev.biochem.73.012803.092429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026044021
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1146/annurev.biophys.30.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045805391
128 rdf:type schema:CreativeWork
129 https://www.grid.ac/institutes/grid.410828.7 schema:Organization
130 https://www.grid.ac/institutes/grid.7597.c schema:Organization
 




Preview window. Press ESC to close (or click here)


...