High affinity NY-ESO T cell receptor


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

DUNN STEVEN MARK , JONATHAN MICHAEL BOULTER , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , STEVEN MARK DUNN

ABSTRACT

The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC (SEQ ID NO:126) peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower. More... »

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