DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

David W. Ow , Richard Calendar , Lynn Thomason

ABSTRACT

This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the ΦC31 integrase, that can mediate recombination between the recombination sites, but not between hybrid recombination sites that are formed upon the recombination. Thus, the recombination is irreversible in the absence of additional factors. Eukaryotic cells that contain the recombinase polypeptides, or genes that encode the recombinases, are also provided. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "David W. Ow", 
        "type": "Person"
      }, 
      {
        "name": "Richard Calendar", 
        "type": "Person"
      }, 
      {
        "name": "Lynn Thomason", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.161269798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000619034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(92)91023-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001891302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.1.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003303640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jexbot/51.346.853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003951254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.4.868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005837712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00290396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006024392", 
          "https://doi.org/10.1007/bf00290396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00290396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006024392", 
          "https://doi.org/10.1007/bf00290396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.10.6634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006997795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.5.1706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.4.930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011600775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.12.7203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012262651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.9.4509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012315307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.12.3926-3934.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012411175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0093-691x(95)00355-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014442498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.12.6104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016067852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.090527097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016141545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(83)90331-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016453858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(90)90165-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017367959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.2001.01067.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017618212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0958-1669(00)00188-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017700444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.1994.6060957.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017850585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00034962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018704441", 
          "https://doi.org/10.1007/bf00034962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00034962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018704441", 
          "https://doi.org/10.1007/bf00034962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.1997.11050945.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018823521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(00)01394-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020265012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.1999.01493.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020333810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.11.5586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021671685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.20.11117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022013134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02762320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022280170", 
          "https://doi.org/10.1007/bf02762320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02762320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022280170", 
          "https://doi.org/10.1007/bf02762320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/84428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022691725", 
          "https://doi.org/10.1038/84428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023076349", 
          "https://doi.org/10.1038/nbt787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/23.3.485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024625009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.2001.01068.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024813886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.1994.05020299.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025460232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.arplant.47.1.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027327549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00041406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027472940", 
          "https://doi.org/10.1007/bf00041406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00041406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027472940", 
          "https://doi.org/10.1007/bf00041406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/26.11.2729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028941224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.240471297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030382092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.7.3094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031106044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004120000079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033841055", 
          "https://doi.org/10.1007/s004120000079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004120000079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033841055", 
          "https://doi.org/10.1007/s004120000079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90213-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034027105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/24.19.3784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034359780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.7.2938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035298778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1994.1671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036308139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(93)90551-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036420154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(00)00008-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037217040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.7.3358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037372824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.1.353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037543751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00224045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039083413", 
          "https://doi.org/10.1007/bf00224045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00224045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039083413", 
          "https://doi.org/10.1007/bf00224045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.1995.tb02417.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039173802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/23.11.1923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039929956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/50.338.1447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040295909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.1995.7040649.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040402163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m011725200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040810998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0958-1669(93)90118-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043757104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.849600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044230906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-313x.1994.05020285.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044891709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/21.4.969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045289223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1999.3113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045592383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.3532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051981081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004380100498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052553073", 
          "https://doi.org/10.1007/s004380100498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.9.8.1251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053084686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-9525(92)90176-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054554914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi962443e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055212990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi980288t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055215578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1104/pp.102.4.1077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060840046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1900642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062512930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2536191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062542748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.290.5493.979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062571968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.172.2.1092-1098.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062718605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.173.13.4079-4087.1991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062719499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.178.11.3374-3376.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062724893"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "description": "

This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the ΦC31 integrase, that can mediate recombination between the recombination sites, but not between hybrid recombination sites that are formed upon the recombination. Thus, the recombination is irreversible in the absence of additional factors. Eukaryotic cells that contain the recombinase polypeptides, or genes that encode the recombinases, are also provided.

", "id": "sg:patent.US-8129598-B2", "keywords": [ "DNA recombination", "eukaryotic cell", "recombination system", "invention", "method", "stable integration", "nucleic acid", "site-specific recombination", "recombinase", "integrase", "Genetic Recombination", "recombination site", "absence", "additional factor", "gene" ], "name": "DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.30389.31", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.463419.d", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8129598-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:33", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_820f844a.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8129598-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8129598-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8129598-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8129598-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      14 PREDICATES      99 URIs      22 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-8129598-B2 schema:about anzsrc-for:2620
2 schema:author N23565e2214ce4a789c0228cf1113fae6
3 schema:citation sg:pub.10.1007/bf00034962
4 sg:pub.10.1007/bf00041406
5 sg:pub.10.1007/bf00224045
6 sg:pub.10.1007/bf00290396
7 sg:pub.10.1007/bf02762320
8 sg:pub.10.1007/s004120000079
9 sg:pub.10.1007/s004380100498
10 sg:pub.10.1038/84428
11 sg:pub.10.1038/nbt787
12 https://doi.org/10.1006/jmbi.1994.1671
13 https://doi.org/10.1006/jmbi.1999.3113
14 https://doi.org/10.1006/jmbi.2000.3532
15 https://doi.org/10.1016/0022-2836(92)91023-i
16 https://doi.org/10.1016/0092-8674(83)90331-8
17 https://doi.org/10.1016/0092-8674(88)90213-9
18 https://doi.org/10.1016/0093-691x(95)00355-c
19 https://doi.org/10.1016/0168-9525(92)90176-5
20 https://doi.org/10.1016/0378-1119(90)90165-n
21 https://doi.org/10.1016/0378-1119(93)90551-d
22 https://doi.org/10.1016/0958-1669(93)90118-g
23 https://doi.org/10.1016/s0014-5793(00)01394-6
24 https://doi.org/10.1016/s0378-1119(00)00008-1
25 https://doi.org/10.1016/s0958-1669(00)00188-9
26 https://doi.org/10.1021/bi962443e
27 https://doi.org/10.1021/bi980288t
28 https://doi.org/10.1046/j.1365-2958.1999.01493.x
29 https://doi.org/10.1046/j.1365-313x.1994.05020285.x
30 https://doi.org/10.1046/j.1365-313x.1994.05020299.x
31 https://doi.org/10.1046/j.1365-313x.1994.6060957.x
32 https://doi.org/10.1046/j.1365-313x.1995.7040649.x
33 https://doi.org/10.1046/j.1365-313x.1997.11050945.x
34 https://doi.org/10.1046/j.1365-313x.2001.01067.x
35 https://doi.org/10.1046/j.1365-313x.2001.01068.x
36 https://doi.org/10.1073/pnas.090527097
37 https://doi.org/10.1073/pnas.161269798
38 https://doi.org/10.1073/pnas.240471297
39 https://doi.org/10.1073/pnas.91.5.1706
40 https://doi.org/10.1073/pnas.93.7.3094
41 https://doi.org/10.1073/pnas.94.12.6104
42 https://doi.org/10.1073/pnas.95.12.7203
43 https://doi.org/10.1073/pnas.96.20.11117
44 https://doi.org/10.1073/pnas.97.7.3358
45 https://doi.org/10.1074/jbc.270.7.2938
46 https://doi.org/10.1074/jbc.274.10.6634
47 https://doi.org/10.1074/jbc.m011725200
48 https://doi.org/10.1093/jexbot/51.346.853
49 https://doi.org/10.1093/jxb/50.338.1447
50 https://doi.org/10.1093/nar/21.4.969
51 https://doi.org/10.1093/nar/23.11.1923
52 https://doi.org/10.1093/nar/23.3.485
53 https://doi.org/10.1093/nar/24.19.3784
54 https://doi.org/10.1093/nar/25.4.868
55 https://doi.org/10.1093/nar/26.11.2729
56 https://doi.org/10.1093/nar/27.4.930
57 https://doi.org/10.1101/gad.8.1.74
58 https://doi.org/10.1101/gad.849600
59 https://doi.org/10.1104/pp.102.4.1077
60 https://doi.org/10.1105/tpc.9.8.1251
61 https://doi.org/10.1111/j.1365-2958.1995.tb02417.x
62 https://doi.org/10.1126/science.1900642
63 https://doi.org/10.1126/science.2536191
64 https://doi.org/10.1126/science.290.5493.979
65 https://doi.org/10.1128/jb.172.2.1092-1098.1990
66 https://doi.org/10.1128/jb.173.13.4079-4087.1991
67 https://doi.org/10.1128/jb.178.11.3374-3376.1996
68 https://doi.org/10.1128/mcb.10.1.353
69 https://doi.org/10.1128/mcb.11.11.5586
70 https://doi.org/10.1128/mcb.11.9.4509
71 https://doi.org/10.1128/mcb.21.12.3926-3934.2001
72 https://doi.org/10.1146/annurev.arplant.47.1.23
73 schema:description <p id="p-0001" num="0000">This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the &#934;C31 integrase, that can mediate recombination between the recombination sites, but not between hybrid recombination sites that are formed upon the recombination. Thus, the recombination is irreversible in the absence of additional factors. Eukaryotic cells that contain the recombinase polypeptides, or genes that encode the recombinases, are also provided.</p>
74 schema:keywords DNA recombination
75 Genetic Recombination
76 absence
77 additional factor
78 eukaryotic cell
79 gene
80 integrase
81 invention
82 method
83 nucleic acid
84 recombinase
85 recombination site
86 recombination system
87 site-specific recombination
88 stable integration
89 schema:name DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
90 schema:recipient https://www.grid.ac/institutes/grid.30389.31
91 https://www.grid.ac/institutes/grid.463419.d
92 schema:sameAs https://app.dimensions.ai/details/patent/US-8129598-B2
93 schema:sdDatePublished 2019-03-07T15:33
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N57e1ead9ee674a2a9b64d9adc70f319e
96 sgo:license sg:explorer/license/
97 sgo:sdDataset patents
98 rdf:type sgo:Patent
99 N1d01bd03a55e4062a4761e2fffeac17f schema:name David W. Ow
100 rdf:type schema:Person
101 N23565e2214ce4a789c0228cf1113fae6 rdf:first N1d01bd03a55e4062a4761e2fffeac17f
102 rdf:rest Nf9d812958f6f48adbbfc069685a5cfac
103 N57e1ead9ee674a2a9b64d9adc70f319e schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 Naf15d525297243cb8bdd0ad4670bc844 schema:name Lynn Thomason
106 rdf:type schema:Person
107 Nb12f96061cc444be9afaa0894c0ca139 rdf:first Naf15d525297243cb8bdd0ad4670bc844
108 rdf:rest rdf:nil
109 Nb1b122339e9c463f88a3507957d4e376 schema:name Richard Calendar
110 rdf:type schema:Person
111 Nf9d812958f6f48adbbfc069685a5cfac rdf:first Nb1b122339e9c463f88a3507957d4e376
112 rdf:rest Nb12f96061cc444be9afaa0894c0ca139
113 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
114 rdf:type schema:DefinedTerm
115 sg:pub.10.1007/bf00034962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018704441
116 https://doi.org/10.1007/bf00034962
117 rdf:type schema:CreativeWork
118 sg:pub.10.1007/bf00041406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027472940
119 https://doi.org/10.1007/bf00041406
120 rdf:type schema:CreativeWork
121 sg:pub.10.1007/bf00224045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039083413
122 https://doi.org/10.1007/bf00224045
123 rdf:type schema:CreativeWork
124 sg:pub.10.1007/bf00290396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006024392
125 https://doi.org/10.1007/bf00290396
126 rdf:type schema:CreativeWork
127 sg:pub.10.1007/bf02762320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022280170
128 https://doi.org/10.1007/bf02762320
129 rdf:type schema:CreativeWork
130 sg:pub.10.1007/s004120000079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033841055
131 https://doi.org/10.1007/s004120000079
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s004380100498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052553073
134 https://doi.org/10.1007/s004380100498
135 rdf:type schema:CreativeWork
136 sg:pub.10.1038/84428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022691725
137 https://doi.org/10.1038/84428
138 rdf:type schema:CreativeWork
139 sg:pub.10.1038/nbt787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023076349
140 https://doi.org/10.1038/nbt787
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1006/jmbi.1994.1671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036308139
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1006/jmbi.1999.3113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045592383
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1006/jmbi.2000.3532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051981081
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/0022-2836(92)91023-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1001891302
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/0092-8674(83)90331-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016453858
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/0092-8674(88)90213-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034027105
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/0093-691x(95)00355-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1014442498
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/0168-9525(92)90176-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054554914
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/0378-1119(90)90165-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1017367959
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/0378-1119(93)90551-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1036420154
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/0958-1669(93)90118-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1043757104
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/s0014-5793(00)01394-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020265012
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/s0378-1119(00)00008-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037217040
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/s0958-1669(00)00188-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017700444
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1021/bi962443e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055212990
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1021/bi980288t schema:sameAs https://app.dimensions.ai/details/publication/pub.1055215578
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1046/j.1365-2958.1999.01493.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020333810
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1046/j.1365-313x.1994.05020285.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044891709
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1046/j.1365-313x.1994.05020299.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025460232
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1046/j.1365-313x.1994.6060957.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017850585
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1046/j.1365-313x.1995.7040649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040402163
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1046/j.1365-313x.1997.11050945.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018823521
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1046/j.1365-313x.2001.01067.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017618212
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1046/j.1365-313x.2001.01068.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024813886
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1073/pnas.090527097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016141545
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1073/pnas.161269798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000619034
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1073/pnas.240471297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030382092
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1073/pnas.91.5.1706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225663
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1073/pnas.93.7.3094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031106044
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1073/pnas.94.12.6104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016067852
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1073/pnas.95.12.7203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012262651
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1073/pnas.96.20.11117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022013134
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1073/pnas.97.7.3358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037372824
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1074/jbc.270.7.2938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035298778
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1074/jbc.274.10.6634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006997795
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1074/jbc.m011725200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040810998
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1093/jexbot/51.346.853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003951254
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/jxb/50.338.1447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040295909
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/nar/21.4.969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045289223
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/nar/23.11.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039929956
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/nar/23.3.485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024625009
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1093/nar/24.19.3784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034359780
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1093/nar/25.4.868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005837712
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1093/nar/26.11.2729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028941224
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1093/nar/27.4.930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011600775
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1101/gad.8.1.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003303640
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1101/gad.849600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044230906
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1104/pp.102.4.1077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060840046
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1105/tpc.9.8.1251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053084686
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1111/j.1365-2958.1995.tb02417.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039173802
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1126/science.1900642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062512930
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.2536191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542748
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.290.5493.979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571968
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1128/jb.172.2.1092-1098.1990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062718605
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1128/jb.173.13.4079-4087.1991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062719499
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1128/jb.178.11.3374-3376.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062724893
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1128/mcb.10.1.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543751
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1128/mcb.11.11.5586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021671685
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1128/mcb.11.9.4509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012315307
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1128/mcb.21.12.3926-3934.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012411175
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1146/annurev.arplant.47.1.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027327549
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.30389.31 schema:Organization
265 https://www.grid.ac/institutes/grid.463419.d schema:Organization
 




Preview window. Press ESC to close (or click here)


...