Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Shinya Yamanaka , Kazutoshi Takahashi , Keisuke Okita

ABSTRACT

The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells. More... »

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    The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.

    ", "id": "sg:patent.US-8129187-B2", "keywords": [ "somatic cell", "retroviral vector", "KLF4", "c-myc", "invention", "nuclear reprogramming", "induced pluripotent stem", "cell", "induced pluripotent stem cell", "method", "Mass Screening", "testing method", "stem cell therapy" ], "name": "Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.258799.8", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8129187-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:33", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_820f844a.jsonl", "type": "Patent" } ]
     

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