Method for producing temperature sensitive influenza A viruses


Ontology type: sgo:Patent     


Patent Info

DATE

2012-02-14T00:00

AUTHORS

HOFFMANN ERICH , JIN HONG , LU BIN , DUKE GREGORY , KEMBLE GEORGE , CHEN ZHONGYING

ABSTRACT

Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided. More... »

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