Method of treating cancer by inhibition of p95HER-2 production


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Gail M. Clinton

ABSTRACT

There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western blotting). Moreover, immunoprecipitations using domain specific antibodies was able to utilize this specific polypeptide from intracellular fragments as a diagnostic and prognostic indicator of adenomacarcinomas without the severe dilution effects encountered by measuring ECD. More... »

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