Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, ...


Ontology type: sgo:Patent     


Patent Info

DATE

2011-12-27T00:00

AUTHORS

HELLERSTEIN MARC K

ABSTRACT

Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessible to direct sampling by sampling metabolic derivatives and catabolic products in accessible biological samples are disclosed herein. More... »

Related SciGraph Publications

  • 1997-05. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies in NATURE MEDICINE
  • 1999-01. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans in NATURE MEDICINE
  • 2007-08-01. Quantitative mass spectrometry in proteomics: a critical review in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 1995-01. Viral dynamics in human immunodeficiency virus type 1 infection in NATURE
  • 1995-07. T-cell dynamics of immunodeficiency in NATURE MEDICINE
  • 1998-02. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy in NATURE MEDICINE
  • 2001-06-01. Elimination of the concentration dependence in mass isotopomer abundance mass spectrometry of methyl palmitate using metastable atom bombardment in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 1997-05. Decay characteristics of HIV-1-infected compartments during combination therapy in NATURE
  • 1995-07. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection in NATURE MEDICINE
  • 1992-11. Lifespan of human lymphocyte subsets defined by CD45 isoforms in NATURE
  • 2000-01-01. Proteome analysis using selective incorporation of isotopically labeled amino acids in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 1995-01. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection in NATURE
  • 1978-12. Cell population kinetics in the epithelium of the colon of the male rat in CELL PATHOLOGY
  • 1995-05. CD4+ cell turnover in NATURE
  • 2000-07-25. De novo lipogenesis in adipose tissue of lean and obese women: application of deuterated water and isotope ratio mass spectrometry in INTERNATIONAL JOURNAL OF OBESITY
  • 1999-05-01. Molecular ion fragmentation and its effects on mass isotopomer abundances of fatty acid methyl esters ionized by electron impact in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • 2004-02-01. From monoamines to genomic targets: a paradigm shift for drug discovery in depression in NATURE REVIEWS DRUG DISCOVERY
  • 1995-09. Role of apoptosis in HIV disease pathogenesis in JOURNAL OF CLINICAL IMMUNOLOGY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "HELLERSTEIN MARC K", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/375193b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018438812", 
              "https://doi.org/10.1038/375193b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051733099", 
              "https://doi.org/10.1038/4772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387188a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026180202", 
              "https://doi.org/10.1038/387188a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02889556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086245900", 
              "https://doi.org/10.1007/bf02889556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0795-674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000284466", 
              "https://doi.org/10.1038/nm0795-674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1044-0305(99)00120-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003136388", 
              "https://doi.org/10.1016/s1044-0305(99)00120-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373117a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025418642", 
              "https://doi.org/10.1038/373117a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0298-215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040912634", 
              "https://doi.org/10.1038/nm0298-215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0801256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027399842", 
              "https://doi.org/10.1038/sj.ijo.0801256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01540879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022605986", 
              "https://doi.org/10.1007/bf01540879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0597-533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002856145", 
              "https://doi.org/10.1038/nm0597-533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/360264a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017658165", 
              "https://doi.org/10.1038/360264a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0795-621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050391753", 
              "https://doi.org/10.1038/nm0795-621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003179281", 
              "https://doi.org/10.1038/nrd1303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-007-1486-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001825252", 
              "https://doi.org/10.1007/s00216-007-1486-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1044-0305(99)00003-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020130566", 
              "https://doi.org/10.1016/s1044-0305(99)00003-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373123a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014949926", 
              "https://doi.org/10.1038/373123a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1044-0305(01)00227-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053222022", 
              "https://doi.org/10.1016/s1044-0305(01)00227-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-12-27T00:00", 
        "description": "

    Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessible to direct sampling by sampling metabolic derivatives and catabolic products in accessible biological samples are disclosed herein.

    ", "endDate": "2025-01-10", "id": "sg:patent.US-8084016-B2", "name": "Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.30389.31", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-8084016-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_52.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-8084016-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-8084016-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-8084016-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-8084016-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    98 TRIPLES      15 PREDICATES      34 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-8084016-B2 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N8fb6ba96b8f14b6e95c61f5e9c0c4f50
    4 schema:citation sg:pub.10.1007/bf01540879
    5 sg:pub.10.1007/bf02889556
    6 sg:pub.10.1007/s00216-007-1486-6
    7 sg:pub.10.1016/s1044-0305(01)00227-6
    8 sg:pub.10.1016/s1044-0305(99)00003-3
    9 sg:pub.10.1016/s1044-0305(99)00120-8
    10 sg:pub.10.1038/360264a0
    11 sg:pub.10.1038/373117a0
    12 sg:pub.10.1038/373123a0
    13 sg:pub.10.1038/375193b0
    14 sg:pub.10.1038/387188a0
    15 sg:pub.10.1038/4772
    16 sg:pub.10.1038/nm0298-215
    17 sg:pub.10.1038/nm0597-533
    18 sg:pub.10.1038/nm0795-621
    19 sg:pub.10.1038/nm0795-674
    20 sg:pub.10.1038/nrd1303
    21 sg:pub.10.1038/sj.ijo.0801256
    22 schema:datePublished 2011-12-27T00:00
    23 schema:description <p num="p-0001">Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessible to direct sampling by sampling metabolic derivatives and catabolic products in accessible biological samples are disclosed herein.</p>
    24 schema:endDate 2025-01-10
    25 schema:name Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products
    26 schema:recipient grid-institutes:grid.30389.31
    27 schema:sameAs https://app.dimensions.ai/details/patent/US-8084016-B2
    28 schema:sdDatePublished 2022-09-02T16:21
    29 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    30 schema:sdPublisher Nb727cf2782ed4416a8e353951ba4adb0
    31 sgo:license sg:explorer/license/
    32 sgo:sdDataset patents
    33 rdf:type sgo:Patent
    34 N3f7333ec4957419286e48287428f4505 schema:name HELLERSTEIN MARC K
    35 rdf:type schema:Person
    36 N8fb6ba96b8f14b6e95c61f5e9c0c4f50 rdf:first N3f7333ec4957419286e48287428f4505
    37 rdf:rest rdf:nil
    38 Nb727cf2782ed4416a8e353951ba4adb0 schema:name Springer Nature - SN SciGraph project
    39 rdf:type schema:Organization
    40 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    41 rdf:type schema:DefinedTerm
    42 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    43 rdf:type schema:DefinedTerm
    44 sg:pub.10.1007/bf01540879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022605986
    45 https://doi.org/10.1007/bf01540879
    46 rdf:type schema:CreativeWork
    47 sg:pub.10.1007/bf02889556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086245900
    48 https://doi.org/10.1007/bf02889556
    49 rdf:type schema:CreativeWork
    50 sg:pub.10.1007/s00216-007-1486-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001825252
    51 https://doi.org/10.1007/s00216-007-1486-6
    52 rdf:type schema:CreativeWork
    53 sg:pub.10.1016/s1044-0305(01)00227-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053222022
    54 https://doi.org/10.1016/s1044-0305(01)00227-6
    55 rdf:type schema:CreativeWork
    56 sg:pub.10.1016/s1044-0305(99)00003-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020130566
    57 https://doi.org/10.1016/s1044-0305(99)00003-3
    58 rdf:type schema:CreativeWork
    59 sg:pub.10.1016/s1044-0305(99)00120-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003136388
    60 https://doi.org/10.1016/s1044-0305(99)00120-8
    61 rdf:type schema:CreativeWork
    62 sg:pub.10.1038/360264a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017658165
    63 https://doi.org/10.1038/360264a0
    64 rdf:type schema:CreativeWork
    65 sg:pub.10.1038/373117a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025418642
    66 https://doi.org/10.1038/373117a0
    67 rdf:type schema:CreativeWork
    68 sg:pub.10.1038/373123a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014949926
    69 https://doi.org/10.1038/373123a0
    70 rdf:type schema:CreativeWork
    71 sg:pub.10.1038/375193b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018438812
    72 https://doi.org/10.1038/375193b0
    73 rdf:type schema:CreativeWork
    74 sg:pub.10.1038/387188a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026180202
    75 https://doi.org/10.1038/387188a0
    76 rdf:type schema:CreativeWork
    77 sg:pub.10.1038/4772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051733099
    78 https://doi.org/10.1038/4772
    79 rdf:type schema:CreativeWork
    80 sg:pub.10.1038/nm0298-215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040912634
    81 https://doi.org/10.1038/nm0298-215
    82 rdf:type schema:CreativeWork
    83 sg:pub.10.1038/nm0597-533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002856145
    84 https://doi.org/10.1038/nm0597-533
    85 rdf:type schema:CreativeWork
    86 sg:pub.10.1038/nm0795-621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050391753
    87 https://doi.org/10.1038/nm0795-621
    88 rdf:type schema:CreativeWork
    89 sg:pub.10.1038/nm0795-674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000284466
    90 https://doi.org/10.1038/nm0795-674
    91 rdf:type schema:CreativeWork
    92 sg:pub.10.1038/nrd1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003179281
    93 https://doi.org/10.1038/nrd1303
    94 rdf:type schema:CreativeWork
    95 sg:pub.10.1038/sj.ijo.0801256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027399842
    96 https://doi.org/10.1038/sj.ijo.0801256
    97 rdf:type schema:CreativeWork
    98 grid-institutes:grid.30389.31 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...