In vitro evolution in microfluidic systems


Ontology type: sgo:Patent     


Patent Info

DATE

2011-06-28T00:00

AUTHORS

Andrew Griffiths , David Weitz , Keunho Ahn , Darren R. Link , Jerome Bibette

ABSTRACT

The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. More... »

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