Isolated aquaporin in its closed conformation


Ontology type: sgo:Patent     


Patent Info

DATE

2011-04-05T00:00

AUTHORS

Per Kjellbom , Kristina Hedfalk , Susanna Törnroth , Maria Ekerot , Urban Johansson , Richard Neutze

ABSTRACT

The invention relates to an isolated aquaporin having a bound ligand, wherein said ligand close the conformation of said aquaporin and inhibit and/or reduce water transport of said aquaporin, and/or a high resolution structure of an isolated aquaporin in a closed conformation characterized by the coordinates deposited at the Protein Data Bank ID:1Z98 and as set forth in Appendix 1, a crystal of said isolated aquaporin as well as the coordinates defining said crystal and the use of said aquaporin, and the use of the high-resolution structure as defined by the coordinates deposited at PDB ID:1Z98 and as set forth in Appendix 1, and a method to produce said aquaporin. More... »

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