Notch receptor specific immunoglobulin for use in diagnosis, prevention and treatment of cell proliferative disorders


Ontology type: sgo:Patent     


Patent Info

DATE

2011-04-05T00:00

AUTHORS

LEWICKI JOHN A , GURNEY AUSTIN , HOEY TIMOTHY , YEN WAN-CHING , SATYAL SANJEEV

ABSTRACT

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells. More... »

Related SciGraph Publications

  • 2000-06-29. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays in ONCOGENE
  • 2006-04-13. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia in NATURE REVIEWS CANCER
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2005-06. Notch signals control the fate of immature progenitor cells in the intestine in NATURE
  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2005-06. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells in NATURE
  • 2007-02-14. Vessel guidance in NATURE
  • 2000-01-13. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines in ONCOGENE
  • 1995-09. Signalling downstream of activated mammalian Notch in NATURE
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
  • 2005-06-12. Notch signaling controls the generation and differentiation of early T lineage progenitors in NATURE IMMUNOLOGY
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "LEWICKI JOHN A", 
            "type": "Person"
          }, 
          {
            "name": "GURNEY AUSTIN", 
            "type": "Person"
          }, 
          {
            "name": "HOEY TIMOTHY", 
            "type": "Person"
          }, 
          {
            "name": "YEN WAN-CHING", 
            "type": "Person"
          }, 
          {
            "name": "SATYAL SANJEEV", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nm754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013090465", 
              "https://doi.org/10.1038/nm754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367645a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028822583", 
              "https://doi.org/10.1038/367645a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424763", 
              "https://doi.org/10.1038/ni1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383707a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043218935", 
              "https://doi.org/10.1038/383707a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377355a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019765251", 
              "https://doi.org/10.1038/377355a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35102167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021100179", 
              "https://doi.org/10.1038/35102167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050959167", 
              "https://doi.org/10.1038/nrc1880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/445722a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002673152", 
              "https://doi.org/10.1038/445722a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029200703", 
              "https://doi.org/10.1038/sj.onc.1203703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015449829", 
              "https://doi.org/10.1038/nature03589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046707660", 
              "https://doi.org/10.1038/nature03659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/81390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039701921", 
              "https://doi.org/10.1038/81390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053478064", 
              "https://doi.org/10.1038/sj.onc.1203295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043382175", 
              "https://doi.org/10.1038/ni1216"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-04-05T00:00", 
        "description": "

    The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.

    ", "endDate": "2028-02-21", "id": "sg:patent.US-7919092-B2", "name": "Notch receptor specific immunoglobulin for use in diagnosis, prevention and treatment of cell proliferative disorders", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.467496.e", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-7919092-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_20.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7919092-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7919092-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7919092-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7919092-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    104 TRIPLES      15 PREDICATES      32 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-7919092-B2 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 anzsrc-for:11
    4 anzsrc-for:1112
    5 schema:author Nf86b5c670583441ca31eb8b9d4770b24
    6 schema:citation sg:pub.10.1038/35102167
    7 sg:pub.10.1038/367645a0
    8 sg:pub.10.1038/377355a0
    9 sg:pub.10.1038/383707a0
    10 sg:pub.10.1038/445722a
    11 sg:pub.10.1038/81390
    12 sg:pub.10.1038/nature03589
    13 sg:pub.10.1038/nature03659
    14 sg:pub.10.1038/ni1164
    15 sg:pub.10.1038/ni1216
    16 sg:pub.10.1038/nm754
    17 sg:pub.10.1038/nrc1880
    18 sg:pub.10.1038/sj.onc.1203295
    19 sg:pub.10.1038/sj.onc.1203703
    20 schema:datePublished 2011-04-05T00:00
    21 schema:description <p num="p-0001">The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.</p>
    22 schema:endDate 2028-02-21
    23 schema:name Notch receptor specific immunoglobulin for use in diagnosis, prevention and treatment of cell proliferative disorders
    24 schema:recipient grid-institutes:grid.467496.e
    25 schema:sameAs https://app.dimensions.ai/details/patent/US-7919092-B2
    26 schema:sdDatePublished 2022-09-02T16:21
    27 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    28 schema:sdPublisher N99c9b0c04d1b4075bb68161e83effd98
    29 sgo:license sg:explorer/license/
    30 sgo:sdDataset patents
    31 rdf:type sgo:Patent
    32 N28b368791aab4937b5d19750b2c8443b schema:name SATYAL SANJEEV
    33 rdf:type schema:Person
    34 N3c43ef1ddc454e5ab4c7e393aa5ae0eb rdf:first Nc2c23f3063ff4633a0d628e0061d989e
    35 rdf:rest Ned109ead6b734b96826a6a3b2f2edff9
    36 N653716466fae4bfe802fb5d83187a164 schema:name YEN WAN-CHING
    37 rdf:type schema:Person
    38 N661789b10bfa47229dcfb0f38b655888 rdf:first N653716466fae4bfe802fb5d83187a164
    39 rdf:rest N95fa6e1a76a04721ac6d20a24a3ed0df
    40 N95fa6e1a76a04721ac6d20a24a3ed0df rdf:first N28b368791aab4937b5d19750b2c8443b
    41 rdf:rest rdf:nil
    42 N99c9b0c04d1b4075bb68161e83effd98 schema:name Springer Nature - SN SciGraph project
    43 rdf:type schema:Organization
    44 Nbeb5e6571e6c4a26ba29321e9dfc223a schema:name LEWICKI JOHN A
    45 rdf:type schema:Person
    46 Nc2c23f3063ff4633a0d628e0061d989e schema:name GURNEY AUSTIN
    47 rdf:type schema:Person
    48 Ned109ead6b734b96826a6a3b2f2edff9 rdf:first Nf579039358ae4635bdae5571b87e5efa
    49 rdf:rest N661789b10bfa47229dcfb0f38b655888
    50 Nf579039358ae4635bdae5571b87e5efa schema:name HOEY TIMOTHY
    51 rdf:type schema:Person
    52 Nf86b5c670583441ca31eb8b9d4770b24 rdf:first Nbeb5e6571e6c4a26ba29321e9dfc223a
    53 rdf:rest N3c43ef1ddc454e5ab4c7e393aa5ae0eb
    54 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    55 rdf:type schema:DefinedTerm
    56 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    57 rdf:type schema:DefinedTerm
    58 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    59 rdf:type schema:DefinedTerm
    60 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    61 rdf:type schema:DefinedTerm
    62 sg:pub.10.1038/35102167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100179
    63 https://doi.org/10.1038/35102167
    64 rdf:type schema:CreativeWork
    65 sg:pub.10.1038/367645a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028822583
    66 https://doi.org/10.1038/367645a0
    67 rdf:type schema:CreativeWork
    68 sg:pub.10.1038/377355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019765251
    69 https://doi.org/10.1038/377355a0
    70 rdf:type schema:CreativeWork
    71 sg:pub.10.1038/383707a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043218935
    72 https://doi.org/10.1038/383707a0
    73 rdf:type schema:CreativeWork
    74 sg:pub.10.1038/445722a schema:sameAs https://app.dimensions.ai/details/publication/pub.1002673152
    75 https://doi.org/10.1038/445722a
    76 rdf:type schema:CreativeWork
    77 sg:pub.10.1038/81390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039701921
    78 https://doi.org/10.1038/81390
    79 rdf:type schema:CreativeWork
    80 sg:pub.10.1038/nature03589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015449829
    81 https://doi.org/10.1038/nature03589
    82 rdf:type schema:CreativeWork
    83 sg:pub.10.1038/nature03659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707660
    84 https://doi.org/10.1038/nature03659
    85 rdf:type schema:CreativeWork
    86 sg:pub.10.1038/ni1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424763
    87 https://doi.org/10.1038/ni1164
    88 rdf:type schema:CreativeWork
    89 sg:pub.10.1038/ni1216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043382175
    90 https://doi.org/10.1038/ni1216
    91 rdf:type schema:CreativeWork
    92 sg:pub.10.1038/nm754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013090465
    93 https://doi.org/10.1038/nm754
    94 rdf:type schema:CreativeWork
    95 sg:pub.10.1038/nrc1880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050959167
    96 https://doi.org/10.1038/nrc1880
    97 rdf:type schema:CreativeWork
    98 sg:pub.10.1038/sj.onc.1203295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053478064
    99 https://doi.org/10.1038/sj.onc.1203295
    100 rdf:type schema:CreativeWork
    101 sg:pub.10.1038/sj.onc.1203703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029200703
    102 https://doi.org/10.1038/sj.onc.1203703
    103 rdf:type schema:CreativeWork
    104 grid-institutes:grid.467496.e schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...