Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera


Ontology type: sgo:Patent     


Patent Info

DATE

2010-10-26T00:00

AUTHORS

Dipanwita Maiti , Shrikant Misiira , Laxmi Srinivas Rao , Milind Prabhakar Nipiiadkar , Ahmed Monsur Borbiiuiya , Ganesh Aruna Khare

ABSTRACT

A way to increase the production of recombinant polypeptides by combining pieces of several different isoforms of a given gene to make a chimeric isoform of the gene (using a chimeric gene can increase the production of polypeptide over 25%), or by inserting several copies of the coding region in tandem into a transformation vector (e.g., plasmids carrying multiple copies of the chimera of SEQ ID NO: 3 increased production 107%). More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Dipanwita Maiti", 
        "type": "Person"
      }, 
      {
        "name": "Shrikant Misiira", 
        "type": "Person"
      }, 
      {
        "name": "Laxmi Srinivas Rao", 
        "type": "Person"
      }, 
      {
        "name": "Milind Prabhakar Nipiiadkar", 
        "type": "Person"
      }, 
      {
        "name": "Ahmed Monsur Borbiiuiya", 
        "type": "Person"
      }, 
      {
        "name": "Ganesh Aruna Khare", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0168-1656(97)00062-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001662949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1985.tb09322.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001773067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/11.12.3939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003926345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-1656(98)00054-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008089446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(80)90363-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010847021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/15.16.6331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012827480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(87)90279-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012836160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(87)90279-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012836160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(85)90239-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013009327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(85)90120-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017120147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(85)90120-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017120147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/9.15.3719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018544808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1186-991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019022620", 
          "https://doi.org/10.1038/nbt1186-991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.74.2.560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021800596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000456320103800504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027380304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/000456320103800504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027380304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1390424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029634543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07435807409089000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030205598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0888-7543(89)90271-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033613417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ph.46.030184.000341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037509597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/281544a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039289365", 
          "https://doi.org/10.1038/281544a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2950719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039464438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2950719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039464438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13813458809079626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039691535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(95)00525-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047890948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2466339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062538904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-128-3-1298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064264073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.80.5.1743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064298255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-51-5-1058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064311385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-71-1-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064316309"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-10-26T00:00", 
    "description": "

A way to increase the production of recombinant polypeptides by combining pieces of several different isoforms of a given gene to make a chimeric isoform of the gene (using a chimeric gene can increase the production of polypeptide over 25%), or by inserting several copies of the coding region in tandem into a transformation vector (e.g., plasmids carrying multiple copies of the chimera of SEQ ID NO: 3 increased production 107%).

", "id": "sg:patent.US-7820409-B2", "keywords": [ "Human Growth Hormone", "placenta", "isoform", "Chimera", "polypeptide", "piece", "different isoforms", "given gene", "gene", "chimeric gene", "copy", "transformation", "plasmid", "multiple copy", "ID", "increased production" ], "name": "Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera", "sameAs": [ "https://app.dimensions.ai/details/patent/US-7820409-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:06", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00123.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7820409-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7820409-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7820409-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7820409-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

136 TRIPLES      14 PREDICATES      55 URIs      24 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-7820409-B2 schema:about anzsrc-for:2620
2 schema:author N69f56de2805c41219851f2e90748587c
3 schema:citation sg:pub.10.1038/281544a0
4 sg:pub.10.1038/nbt1186-991
5 https://doi.org/10.1016/0006-291x(80)90363-0
6 https://doi.org/10.1016/0092-8674(85)90239-9
7 https://doi.org/10.1016/0378-1119(85)90120-9
8 https://doi.org/10.1016/0378-1119(87)90279-4
9 https://doi.org/10.1016/0378-1119(95)00525-b
10 https://doi.org/10.1016/0888-7543(89)90271-1
11 https://doi.org/10.1016/s0168-1656(97)00062-x
12 https://doi.org/10.1016/s0168-1656(98)00054-6
13 https://doi.org/10.1042/bj2950719
14 https://doi.org/10.1073/pnas.74.2.560
15 https://doi.org/10.1093/nar/11.12.3939
16 https://doi.org/10.1093/nar/15.16.6331
17 https://doi.org/10.1093/nar/9.15.3719
18 https://doi.org/10.1111/j.1432-1033.1985.tb09322.x
19 https://doi.org/10.1126/science.2466339
20 https://doi.org/10.1146/annurev.ph.46.030184.000341
21 https://doi.org/10.1177/000456320103800504
22 https://doi.org/10.1210/endo-128-3-1298
23 https://doi.org/10.1210/jc.80.5.1743
24 https://doi.org/10.1210/jcem-51-5-1058
25 https://doi.org/10.1210/jcem-71-1-15
26 https://doi.org/10.1530/eje.0.1390424
27 https://doi.org/10.3109/07435807409089000
28 https://doi.org/10.3109/13813458809079626
29 schema:datePublished 2010-10-26T00:00
30 schema:description <p num="p-0001">A way to increase the production of recombinant polypeptides by combining pieces of several different isoforms of a given gene to make a chimeric isoform of the gene (using a chimeric gene can increase the production of polypeptide over 25%), or by inserting several copies of the coding region in tandem into a transformation vector (e.g., plasmids carrying multiple copies of the chimera of SEQ ID NO: 3 increased production 107%).</p>
31 schema:keywords Chimera
32 Human Growth Hormone
33 ID
34 chimeric gene
35 copy
36 different isoforms
37 gene
38 given gene
39 increased production
40 isoform
41 multiple copy
42 piece
43 placenta
44 plasmid
45 polypeptide
46 transformation
47 schema:name Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera
48 schema:sameAs https://app.dimensions.ai/details/patent/US-7820409-B2
49 schema:sdDatePublished 2019-04-18T10:06
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Nd5845c4cc4914b28b8d9cc46c937922e
52 sgo:license sg:explorer/license/
53 sgo:sdDataset patents
54 rdf:type sgo:Patent
55 N1e53ab4faa3d4391a63eb45bc1206bb2 schema:name Dipanwita Maiti
56 rdf:type schema:Person
57 N2fcd7035769d46d39361d291701a13db schema:name Milind Prabhakar Nipiiadkar
58 rdf:type schema:Person
59 N3c9a221bf2e248808ad15fb7c8434c2a schema:name Ahmed Monsur Borbiiuiya
60 rdf:type schema:Person
61 N5364033859b94a3aaaa38940645418a1 rdf:first N68884f82079941dea3b400fa75d1e991
62 rdf:rest Nf84fcd497f764b10b95c0f0691c5902e
63 N68884f82079941dea3b400fa75d1e991 schema:name Shrikant Misiira
64 rdf:type schema:Person
65 N69f56de2805c41219851f2e90748587c rdf:first N1e53ab4faa3d4391a63eb45bc1206bb2
66 rdf:rest N5364033859b94a3aaaa38940645418a1
67 N6e57ffbdd23e48c38f5168737cb5d683 rdf:first N2fcd7035769d46d39361d291701a13db
68 rdf:rest Nc9bf1a82fc6240f5a9d3a7b826ade189
69 Nc9bf1a82fc6240f5a9d3a7b826ade189 rdf:first N3c9a221bf2e248808ad15fb7c8434c2a
70 rdf:rest Nd20ed20ed0b944a497b69df8c125e20b
71 Nd20ed20ed0b944a497b69df8c125e20b rdf:first Ne9e6f37133a34962a36acf0b35d7ce64
72 rdf:rest rdf:nil
73 Nd5845c4cc4914b28b8d9cc46c937922e schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 Ne9e6f37133a34962a36acf0b35d7ce64 schema:name Ganesh Aruna Khare
76 rdf:type schema:Person
77 Nedf826e60666420981e03cf0bc81b12d schema:name Laxmi Srinivas Rao
78 rdf:type schema:Person
79 Nf84fcd497f764b10b95c0f0691c5902e rdf:first Nedf826e60666420981e03cf0bc81b12d
80 rdf:rest N6e57ffbdd23e48c38f5168737cb5d683
81 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
82 rdf:type schema:DefinedTerm
83 sg:pub.10.1038/281544a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039289365
84 https://doi.org/10.1038/281544a0
85 rdf:type schema:CreativeWork
86 sg:pub.10.1038/nbt1186-991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019022620
87 https://doi.org/10.1038/nbt1186-991
88 rdf:type schema:CreativeWork
89 https://doi.org/10.1016/0006-291x(80)90363-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010847021
90 rdf:type schema:CreativeWork
91 https://doi.org/10.1016/0092-8674(85)90239-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013009327
92 rdf:type schema:CreativeWork
93 https://doi.org/10.1016/0378-1119(85)90120-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017120147
94 rdf:type schema:CreativeWork
95 https://doi.org/10.1016/0378-1119(87)90279-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012836160
96 rdf:type schema:CreativeWork
97 https://doi.org/10.1016/0378-1119(95)00525-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1047890948
98 rdf:type schema:CreativeWork
99 https://doi.org/10.1016/0888-7543(89)90271-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033613417
100 rdf:type schema:CreativeWork
101 https://doi.org/10.1016/s0168-1656(97)00062-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001662949
102 rdf:type schema:CreativeWork
103 https://doi.org/10.1016/s0168-1656(98)00054-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008089446
104 rdf:type schema:CreativeWork
105 https://doi.org/10.1042/bj2950719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039464438
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1073/pnas.74.2.560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021800596
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1093/nar/11.12.3939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003926345
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1093/nar/15.16.6331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012827480
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1093/nar/9.15.3719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018544808
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1111/j.1432-1033.1985.tb09322.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001773067
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1126/science.2466339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062538904
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1146/annurev.ph.46.030184.000341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037509597
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1177/000456320103800504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027380304
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1210/endo-128-3-1298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064264073
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1210/jc.80.5.1743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064298255
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1210/jcem-51-5-1058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064311385
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1210/jcem-71-1-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064316309
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1530/eje.0.1390424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029634543
132 rdf:type schema:CreativeWork
133 https://doi.org/10.3109/07435807409089000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030205598
134 rdf:type schema:CreativeWork
135 https://doi.org/10.3109/13813458809079626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039691535
136 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...