Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same


Ontology type: sgo:Patent     


Patent Info

DATE

2010-10-05T00:00

AUTHORS

Kyung Sun Kang , Jeong Chan Ra , Jung Ran Park

ABSTRACT

This invention relates to human adipose tissue-derived multipotent adult stem cells. More particularly, the invention relates to human adipose tissue-derived multipotent stem cells, which can be maintained in an undifferentiated state for a long period of time by forming spheres and have high proliferation rates, as well as methods for isolating and maintaining the adult stem cells, and methods for differentiating the multipotent adult stem cells into nerve cells, fat cells, cartilage cells, osteogenic cells and insulin-releasing pancreatic beta-cells. Also, the invention relates to cellular therapeutic agents for treating osteoarthritis, osteoporosis and diabetes and for forming breast tissue, which contain the differentiated cells or the adult stem cells. Although the multipotent stem cells are adult stem cells, they have the ability to differentiate into osteogenic cells, nerve cells, astrocytes, fat cells, chrondrogenic cells or insulin-releasing pancreatic beta-cells, and so are effective in treating osteoporosis, osteoarthritis, nerve disease, diabetes, etc. Also, the stem cells form spheres in a serum-free medium containing CORM-2, and thus can be maintained in an undifferentiated state for a long period of time. Also, the stem cells have very high proliferation rates. Accordingly, the stem cells are useful as cellular therapeutic agents. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3053", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2995", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Kyung Sun Kang", 
        "type": "Person"
      }, 
      {
        "name": "Jeong Chan Ra", 
        "type": "Person"
      }, 
      {
        "name": "Jung Ran Park", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1095/biolreprod.105.045138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006074578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.105.045138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006074578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)00469-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008084737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)00469-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008084737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(02)02386-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008127317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(02)02386-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008127317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2004.12.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013127935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015875700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0901-778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018972963", 
          "https://doi.org/10.1038/ncb0901-778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0901-778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018972963", 
          "https://doi.org/10.1038/ncb0901-778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.22-5-649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027396603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20011700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031390513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2003.10.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035562750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040112366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040112366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2004.01.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044180067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000135466.16823.d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051061490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107632701300062859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059205960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2005.14.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059309515"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-10-05T00:00", 
    "description": "

This invention relates to human adipose tissue-derived multipotent adult stem cells. More particularly, the invention relates to human adipose tissue-derived multipotent stem cells, which can be maintained in an undifferentiated state for a long period of time by forming spheres and have high proliferation rates, as well as methods for isolating and maintaining the adult stem cells, and methods for differentiating the multipotent adult stem cells into nerve cells, fat cells, cartilage cells, osteogenic cells and insulin-releasing pancreatic beta-cells. Also, the invention relates to cellular therapeutic agents for treating osteoarthritis, osteoporosis and diabetes and for forming breast tissue, which contain the differentiated cells or the adult stem cells. Although the multipotent stem cells are adult stem cells, they have the ability to differentiate into osteogenic cells, nerve cells, astrocytes, fat cells, chrondrogenic cells or insulin-releasing pancreatic beta-cells, and so are effective in treating osteoporosis, osteoarthritis, nerve disease, diabetes, etc. Also, the stem cells form spheres in a serum-free medium containing CORM-2, and thus can be maintained in an undifferentiated state for a long period of time. Also, the stem cells have very high proliferation rates. Accordingly, the stem cells are useful as cellular therapeutic agents.

", "id": "sg:patent.US-7807461-B2", "keywords": [ "multipotent stem cell", "human adipose tissue", "cellular therapeutic", "invention", "undifferentiated state", "long period", "sphere", "proliferation rate", "method", "adult stem cell", "neuron", "adipocytes", "cartilage cell", "osteogenic cell", "pancreatic beta-cells", "osteoarthritis", "osteoporosis", "diabetes", "breast tissue", "differentiated cell", "astrocyte", "cell", "nerve disease", "stem cell", "serum-free medium" ], "name": "Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same", "sameAs": [ "https://app.dimensions.ai/details/patent/US-7807461-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:06", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00117.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7807461-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7807461-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7807461-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7807461-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

102 TRIPLES      14 PREDICATES      54 URIs      33 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-7807461-B2 schema:about anzsrc-for:2581
2 anzsrc-for:2995
3 anzsrc-for:3053
4 schema:author N8fc87d86a5fb4e68aa98169220e27737
5 schema:citation sg:pub.10.1038/ncb0901-778
6 https://doi.org/10.1002/art.10696
7 https://doi.org/10.1016/j.bbrc.2004.01.053
8 https://doi.org/10.1016/j.bbrc.2004.12.158
9 https://doi.org/10.1016/j.biomaterials.2003.10.045
10 https://doi.org/10.1016/s0006-291x(02)00469-2
11 https://doi.org/10.1016/s0962-8924(02)02386-3
12 https://doi.org/10.1084/jem.20011700
13 https://doi.org/10.1089/107632701300062859
14 https://doi.org/10.1089/scd.2005.14.92
15 https://doi.org/10.1095/biolreprod.105.045138
16 https://doi.org/10.1161/01.cir.0000135466.16823.d0
17 https://doi.org/10.1634/stemcells.2004-0331
18 https://doi.org/10.1634/stemcells.22-5-649
19 schema:datePublished 2010-10-05T00:00
20 schema:description <p num="p-0001">This invention relates to human adipose tissue-derived multipotent adult stem cells. More particularly, the invention relates to human adipose tissue-derived multipotent stem cells, which can be maintained in an undifferentiated state for a long period of time by forming spheres and have high proliferation rates, as well as methods for isolating and maintaining the adult stem cells, and methods for differentiating the multipotent adult stem cells into nerve cells, fat cells, cartilage cells, osteogenic cells and insulin-releasing pancreatic beta-cells. Also, the invention relates to cellular therapeutic agents for treating osteoarthritis, osteoporosis and diabetes and for forming breast tissue, which contain the differentiated cells or the adult stem cells. Although the multipotent stem cells are adult stem cells, they have the ability to differentiate into osteogenic cells, nerve cells, astrocytes, fat cells, chrondrogenic cells or insulin-releasing pancreatic beta-cells, and so are effective in treating osteoporosis, osteoarthritis, nerve disease, diabetes, etc. Also, the stem cells form spheres in a serum-free medium containing CORM-2, and thus can be maintained in an undifferentiated state for a long period of time. Also, the stem cells have very high proliferation rates. Accordingly, the stem cells are useful as cellular therapeutic agents.</p>
21 schema:keywords adipocytes
22 adult stem cell
23 astrocyte
24 breast tissue
25 cartilage cell
26 cell
27 cellular therapeutic
28 diabetes
29 differentiated cell
30 human adipose tissue
31 invention
32 long period
33 method
34 multipotent stem cell
35 nerve disease
36 neuron
37 osteoarthritis
38 osteogenic cell
39 osteoporosis
40 pancreatic beta-cells
41 proliferation rate
42 serum-free medium
43 sphere
44 stem cell
45 undifferentiated state
46 schema:name Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same
47 schema:sameAs https://app.dimensions.ai/details/patent/US-7807461-B2
48 schema:sdDatePublished 2019-04-18T10:06
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N2221ccc1b6f349c5b7858033f6bc2f7e
51 sgo:license sg:explorer/license/
52 sgo:sdDataset patents
53 rdf:type sgo:Patent
54 N1a01c49f43aa4fc0b7c31eab7322cdca schema:name Jung Ran Park
55 rdf:type schema:Person
56 N2221ccc1b6f349c5b7858033f6bc2f7e schema:name Springer Nature - SN SciGraph project
57 rdf:type schema:Organization
58 N363d13e472e241169fd33e921b218743 schema:name Jeong Chan Ra
59 rdf:type schema:Person
60 N3cd9b34188fc4ff3bf2bc00c9ece5327 schema:name Kyung Sun Kang
61 rdf:type schema:Person
62 N5e892eb4eca34694827e8930125e609f rdf:first N363d13e472e241169fd33e921b218743
63 rdf:rest Nf86ab4268dd34a77aa558262c2c4c8c2
64 N8fc87d86a5fb4e68aa98169220e27737 rdf:first N3cd9b34188fc4ff3bf2bc00c9ece5327
65 rdf:rest N5e892eb4eca34694827e8930125e609f
66 Nf86ab4268dd34a77aa558262c2c4c8c2 rdf:first N1a01c49f43aa4fc0b7c31eab7322cdca
67 rdf:rest rdf:nil
68 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
69 rdf:type schema:DefinedTerm
70 anzsrc-for:2995 schema:inDefinedTermSet anzsrc-for:
71 rdf:type schema:DefinedTerm
72 anzsrc-for:3053 schema:inDefinedTermSet anzsrc-for:
73 rdf:type schema:DefinedTerm
74 sg:pub.10.1038/ncb0901-778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018972963
75 https://doi.org/10.1038/ncb0901-778
76 rdf:type schema:CreativeWork
77 https://doi.org/10.1002/art.10696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015875700
78 rdf:type schema:CreativeWork
79 https://doi.org/10.1016/j.bbrc.2004.01.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044180067
80 rdf:type schema:CreativeWork
81 https://doi.org/10.1016/j.bbrc.2004.12.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013127935
82 rdf:type schema:CreativeWork
83 https://doi.org/10.1016/j.biomaterials.2003.10.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035562750
84 rdf:type schema:CreativeWork
85 https://doi.org/10.1016/s0006-291x(02)00469-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008084737
86 rdf:type schema:CreativeWork
87 https://doi.org/10.1016/s0962-8924(02)02386-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008127317
88 rdf:type schema:CreativeWork
89 https://doi.org/10.1084/jem.20011700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031390513
90 rdf:type schema:CreativeWork
91 https://doi.org/10.1089/107632701300062859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059205960
92 rdf:type schema:CreativeWork
93 https://doi.org/10.1089/scd.2005.14.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309515
94 rdf:type schema:CreativeWork
95 https://doi.org/10.1095/biolreprod.105.045138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006074578
96 rdf:type schema:CreativeWork
97 https://doi.org/10.1161/01.cir.0000135466.16823.d0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051061490
98 rdf:type schema:CreativeWork
99 https://doi.org/10.1634/stemcells.2004-0331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040112366
100 rdf:type schema:CreativeWork
101 https://doi.org/10.1634/stemcells.22-5-649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027396603
102 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...