Carboline derivatives useful in the treatment of cancer


Ontology type: sgo:Patent     


Patent Info

DATE

2010-08-03T00:00

AUTHORS

Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis

ABSTRACT

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention. More... »

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