Multifunctional and biologically active matrices from multicomponent polymeric solutions


Ontology type: sgo:Patent     


Patent Info

DATE

2010-06-15T00:00

AUTHORS

Kristi L. Kiick , Nori Yamaguchi

ABSTRACT

The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2447", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Kristi L. Kiick", 
        "type": "Person"
      }, 
      {
        "name": "Nori Yamaguchi", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0266-3538(03)00178-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001647890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0266-3538(03)00178-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001647890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.10167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005365889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/21619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035335278", 
          "https://doi.org/10.1038/21619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bm0342032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055219952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bm0342032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055219952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5375.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561819"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-06-15T00:00", 
    "description": "

The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.

", "id": "sg:patent.US-7737131-B2", "keywords": [ "matrix", "solution", "invention", "immobilization", "long-term delivery", "active agent", "functionalized polymer", "matrix polymer", "polymer", "biomolecules", "molecule", "certain aspect", "polymer fiber", "active molecule", "Low-Molecular-Weight Heparin", "drug", "biopolymers", "growth factor", "protein", "peptide", "nucleotide", "polysaccharide", "biological macromolecule", "hydrogel", "assembly" ], "name": "Multifunctional and biologically active matrices from multicomponent polymeric solutions", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.33489.35", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-7737131-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:05", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00074.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7737131-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7737131-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7737131-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7737131-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

67 TRIPLES      15 PREDICATES      44 URIs      33 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-7737131-B2 schema:about anzsrc-for:2447
2 schema:author Nb400110ff0f34e7f88dd63eb7bb3a124
3 schema:citation sg:pub.10.1038/21619
4 https://doi.org/10.1002/jbm.10167
5 https://doi.org/10.1016/s0266-3538(03)00178-7
6 https://doi.org/10.1021/bm0342032
7 https://doi.org/10.1126/science.281.5375.389
8 schema:datePublished 2010-06-15T00:00
9 schema:description <p num="p-0001">The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.</p>
10 schema:keywords Low-Molecular-Weight Heparin
11 active agent
12 active molecule
13 assembly
14 biological macromolecule
15 biomolecules
16 biopolymers
17 certain aspect
18 drug
19 functionalized polymer
20 growth factor
21 hydrogel
22 immobilization
23 invention
24 long-term delivery
25 matrix
26 matrix polymer
27 molecule
28 nucleotide
29 peptide
30 polymer
31 polymer fiber
32 polysaccharide
33 protein
34 solution
35 schema:name Multifunctional and biologically active matrices from multicomponent polymeric solutions
36 schema:recipient https://www.grid.ac/institutes/grid.33489.35
37 schema:sameAs https://app.dimensions.ai/details/patent/US-7737131-B2
38 schema:sdDatePublished 2019-04-18T10:05
39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
40 schema:sdPublisher N7d85fe323ef64d0283eb3fee460383c9
41 sgo:license sg:explorer/license/
42 sgo:sdDataset patents
43 rdf:type sgo:Patent
44 N31c27994a16849889f2761658ddc81ae rdf:first Ncadac855b1094940b97bb1a11f51e6fb
45 rdf:rest rdf:nil
46 N7d85fe323ef64d0283eb3fee460383c9 schema:name Springer Nature - SN SciGraph project
47 rdf:type schema:Organization
48 Nb400110ff0f34e7f88dd63eb7bb3a124 rdf:first Ndb22fcca117c444396ff8268cc9672ee
49 rdf:rest N31c27994a16849889f2761658ddc81ae
50 Ncadac855b1094940b97bb1a11f51e6fb schema:name Nori Yamaguchi
51 rdf:type schema:Person
52 Ndb22fcca117c444396ff8268cc9672ee schema:name Kristi L. Kiick
53 rdf:type schema:Person
54 anzsrc-for:2447 schema:inDefinedTermSet anzsrc-for:
55 rdf:type schema:DefinedTerm
56 sg:pub.10.1038/21619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035335278
57 https://doi.org/10.1038/21619
58 rdf:type schema:CreativeWork
59 https://doi.org/10.1002/jbm.10167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005365889
60 rdf:type schema:CreativeWork
61 https://doi.org/10.1016/s0266-3538(03)00178-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001647890
62 rdf:type schema:CreativeWork
63 https://doi.org/10.1021/bm0342032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055219952
64 rdf:type schema:CreativeWork
65 https://doi.org/10.1126/science.281.5375.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561819
66 rdf:type schema:CreativeWork
67 https://www.grid.ac/institutes/grid.33489.35 schema:Organization
 




Preview window. Press ESC to close (or click here)


...