Method and composition for treating immune complex associated disorders


Ontology type: sgo:Patent     


Patent Info

DATE

2010-05-04T00:00

AUTHORS

Ann Marshak-Rothstein , Elizabeth A. Leadbetter , Ian R. Rifkin , Mark J. Shlomchik

ABSTRACT

The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR). The methods of treating ICAD comprise administering a compound to an individual in need thereof that either 1) inhibits formation of the immune complex either by preventing formation and/or binding to the TLR, or 2) interferes with binding of an autoantigen-containing immune complex (or the antigenic component thereof) to the TLR, or 3) inhibits signaling pathways initiated by dual engagement of BCR and TLR (in B cells) or FcR and TLR (in dendritic cells) via immune complexed or uncomplexed autoantigens. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Ann Marshak-Rothstein", 
        "type": "Person"
      }, 
      {
        "name": "Elizabeth A. Leadbetter", 
        "type": "Person"
      }, 
      {
        "name": "Ian R. Rifkin", 
        "type": "Person"
      }, 
      {
        "name": "Mark J. Shlomchik", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35047123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001385025", 
          "https://doi.org/10.1038/35047123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35047123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001385025", 
          "https://doi.org/10.1038/35047123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199101173240303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004178612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80402-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006998008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20031942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007777316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.21.6230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012254130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)00380-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015879309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)00380-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015879309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017545108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022213004", 
          "https://doi.org/10.1038/nri844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022213004", 
          "https://doi.org/10.1038/nri844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.18.1.767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023617086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35100573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024339195", 
          "https://doi.org/10.1038/35100573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35100573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024339195", 
          "https://doi.org/10.1038/35100573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/416603a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025072105", 
          "https://doi.org/10.1038/416603a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/416603a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025072105", 
          "https://doi.org/10.1038/416603a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1529-0131(199902)42:2<357::aid-anr19>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027617191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.190.5.639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028403569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/11.12.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029899939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200205)32:5<1212::aid-immu1212>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030165307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-1229(91)90108-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033003838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/416595a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036014223", 
          "https://doi.org/10.1038/416595a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/416595a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036014223", 
          "https://doi.org/10.1038/416595a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/90609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041087790", 
          "https://doi.org/10.1038/90609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/90609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041087790", 
          "https://doi.org/10.1038/90609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/41131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048300852", 
          "https://doi.org/10.1038/41131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/41131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048300852", 
          "https://doi.org/10.1038/41131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0502-423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049282266", 
          "https://doi.org/10.1038/ni0502-423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0502-423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049282266", 
          "https://doi.org/10.1038/ni0502-423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(03)00323-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050287715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2005.00239.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051720591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(95)00115-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052054309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.2.588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053189019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.278.5343.1612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062558826"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-05-04T00:00", 
    "description": "

The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR). The methods of treating ICAD comprise administering a compound to an individual in need thereof that either 1) inhibits formation of the immune complex either by preventing formation and/or binding to the TLR, or 2) interferes with binding of an autoantigen-containing immune complex (or the antigenic component thereof) to the TLR, or 3) inhibits signaling pathways initiated by dual engagement of BCR and TLR (in B cells) or FcR and TLR (in dendritic cells) via immune complexed or uncomplexed autoantigens.

", "id": "sg:patent.US-7709451-B2", "keywords": [ "method", "composition", "associated disorder", "invention", "associated disease", "SLE", "rheumatoid arthritis", "immune complex disease", "risk", "surprising finding", "chromatin", "cell", "dendritic cell", "receptor engagement", "cell type", "Toll-like receptor", "compound", "Antigen-Antibody Complex", "binding", "autoantigens", "antigenic component", "signaling pathway", "engagement" ], "name": "Method and composition for treating immune complex associated disorders", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.189504.1", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.47100.32", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-7709451-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:05", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00060.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7709451-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7709451-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7709451-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7709451-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

142 TRIPLES      15 PREDICATES      63 URIs      31 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-7709451-B2 schema:about anzsrc-for:3103
2 schema:author Naebfdb8cd34f49ca85165b0f12ab5b6f
3 schema:citation sg:pub.10.1038/35047123
4 sg:pub.10.1038/35100573
5 sg:pub.10.1038/41131
6 sg:pub.10.1038/416595a
7 sg:pub.10.1038/416603a
8 sg:pub.10.1038/90609
9 sg:pub.10.1038/ni0502-423
10 sg:pub.10.1038/nri844
11 https://doi.org/10.1002/1521-4141(200205)32:5<1212::aid-immu1212>3.0.co;2-d
12 https://doi.org/10.1002/1529-0131(199902)42:2<357::aid-anr19>3.0.co;2-j
13 https://doi.org/10.1016/0090-1229(91)90108-m
14 https://doi.org/10.1016/0161-5890(95)00115-8
15 https://doi.org/10.1016/s0006-291x(02)00380-7
16 https://doi.org/10.1016/s1074-7613(00)80402-1
17 https://doi.org/10.1016/s1074-7613(03)00323-6
18 https://doi.org/10.1056/nejm199101173240303
19 https://doi.org/10.1073/pnas.95.2.588
20 https://doi.org/10.1084/jem.190.5.639
21 https://doi.org/10.1084/jem.20031942
22 https://doi.org/10.1093/emboj/17.21.6230
23 https://doi.org/10.1093/intimm/11.12.2015
24 https://doi.org/10.1111/j.0105-2896.2005.00239.x
25 https://doi.org/10.1126/science.278.5343.1612
26 https://doi.org/10.1146/annurev.immunol.18.1.767
27 https://doi.org/10.1172/jci114595
28 schema:datePublished 2010-05-04T00:00
29 schema:description <p num="p-0001">The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR). The methods of treating ICAD comprise administering a compound to an individual in need thereof that either 1) inhibits formation of the immune complex either by preventing formation and/or binding to the TLR, or 2) interferes with binding of an autoantigen-containing immune complex (or the antigenic component thereof) to the TLR, or 3) inhibits signaling pathways initiated by dual engagement of BCR and TLR (in B cells) or FcR and TLR (in dendritic cells) via immune complexed or uncomplexed autoantigens.</p>
30 schema:keywords Antigen-Antibody Complex
31 SLE
32 Toll-like receptor
33 antigenic component
34 associated disease
35 associated disorder
36 autoantigens
37 binding
38 cell
39 cell type
40 chromatin
41 composition
42 compound
43 dendritic cell
44 engagement
45 immune complex disease
46 invention
47 method
48 receptor engagement
49 rheumatoid arthritis
50 risk
51 signaling pathway
52 surprising finding
53 schema:name Method and composition for treating immune complex associated disorders
54 schema:recipient https://www.grid.ac/institutes/grid.189504.1
55 https://www.grid.ac/institutes/grid.47100.32
56 schema:sameAs https://app.dimensions.ai/details/patent/US-7709451-B2
57 schema:sdDatePublished 2019-04-18T10:05
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher Nb957580045344b7793c68c78f72e32ea
60 sgo:license sg:explorer/license/
61 sgo:sdDataset patents
62 rdf:type sgo:Patent
63 N55135b0a5baa4b5ca02370efc2bc3847 rdf:first Nbda80c94aa67486cad3b9092ece690b3
64 rdf:rest N83f645957b184150adf628265ed1fc72
65 N83f645957b184150adf628265ed1fc72 rdf:first Nd0eed62e27944ce383a0d55e97b479cb
66 rdf:rest rdf:nil
67 N893b256270304c20a1f652c887e4931f schema:name Elizabeth A. Leadbetter
68 rdf:type schema:Person
69 Na36a82ac53c74889bef0576c7a1f59bb rdf:first N893b256270304c20a1f652c887e4931f
70 rdf:rest N55135b0a5baa4b5ca02370efc2bc3847
71 Naebfdb8cd34f49ca85165b0f12ab5b6f rdf:first Ndd602f971b91430b9769ba9b554c3f3d
72 rdf:rest Na36a82ac53c74889bef0576c7a1f59bb
73 Nb957580045344b7793c68c78f72e32ea schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 Nbda80c94aa67486cad3b9092ece690b3 schema:name Ian R. Rifkin
76 rdf:type schema:Person
77 Nd0eed62e27944ce383a0d55e97b479cb schema:name Mark J. Shlomchik
78 rdf:type schema:Person
79 Ndd602f971b91430b9769ba9b554c3f3d schema:name Ann Marshak-Rothstein
80 rdf:type schema:Person
81 anzsrc-for:3103 schema:inDefinedTermSet anzsrc-for:
82 rdf:type schema:DefinedTerm
83 sg:pub.10.1038/35047123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001385025
84 https://doi.org/10.1038/35047123
85 rdf:type schema:CreativeWork
86 sg:pub.10.1038/35100573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024339195
87 https://doi.org/10.1038/35100573
88 rdf:type schema:CreativeWork
89 sg:pub.10.1038/41131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048300852
90 https://doi.org/10.1038/41131
91 rdf:type schema:CreativeWork
92 sg:pub.10.1038/416595a schema:sameAs https://app.dimensions.ai/details/publication/pub.1036014223
93 https://doi.org/10.1038/416595a
94 rdf:type schema:CreativeWork
95 sg:pub.10.1038/416603a schema:sameAs https://app.dimensions.ai/details/publication/pub.1025072105
96 https://doi.org/10.1038/416603a
97 rdf:type schema:CreativeWork
98 sg:pub.10.1038/90609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041087790
99 https://doi.org/10.1038/90609
100 rdf:type schema:CreativeWork
101 sg:pub.10.1038/ni0502-423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049282266
102 https://doi.org/10.1038/ni0502-423
103 rdf:type schema:CreativeWork
104 sg:pub.10.1038/nri844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022213004
105 https://doi.org/10.1038/nri844
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1002/1521-4141(200205)32:5<1212::aid-immu1212>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1030165307
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1002/1529-0131(199902)42:2<357::aid-anr19>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1027617191
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1016/0090-1229(91)90108-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1033003838
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1016/0161-5890(95)00115-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052054309
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1016/s0006-291x(02)00380-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015879309
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1016/s1074-7613(00)80402-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006998008
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1016/s1074-7613(03)00323-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050287715
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1056/nejm199101173240303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004178612
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1073/pnas.95.2.588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053189019
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1084/jem.190.5.639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028403569
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1084/jem.20031942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007777316
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1093/emboj/17.21.6230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012254130
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1093/intimm/11.12.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029899939
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1111/j.0105-2896.2005.00239.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051720591
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1126/science.278.5343.1612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062558826
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1146/annurev.immunol.18.1.767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023617086
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1172/jci114595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017545108
140 rdf:type schema:CreativeWork
141 https://www.grid.ac/institutes/grid.189504.1 schema:Organization
142 https://www.grid.ac/institutes/grid.47100.32 schema:Organization
 




Preview window. Press ESC to close (or click here)


...