Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2010-04-06T00:00

AUTHORS

Jay Gregory Calvert , Michael G Sheppard , Siao-Kun W. Welch

ABSTRACT

The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Jay Gregory Calvert", 
        "type": "Person"
      }, 
      {
        "name": "Michael G Sheppard", 
        "type": "Person"
      }, 
      {
        "name": "Siao-Kun W. Welch", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.94.3.991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008689203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01322671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011815838", 
          "https://doi.org/10.1007/bf01322671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01322671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011815838", 
          "https://doi.org/10.1007/bf01322671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-1702(97)00134-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013396267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01322667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016657513", 
          "https://doi.org/10.1007/bf01322667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01322667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016657513", 
          "https://doi.org/10.1007/bf01322667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01313785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019690322", 
          "https://doi.org/10.1007/bf01313785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01313785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019690322", 
          "https://doi.org/10.1007/bf01313785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/104063879200400201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031398616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/104063879200400201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031398616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pat.1992.220030602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040892609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01652176.1991.9694296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041373192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01652176.1991.9694297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043183788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-1702(95)01305-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047336278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s007050050316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047361885", 
          "https://doi.org/10.1007/s007050050316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1993.1008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048337583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/104063879400600302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052026899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/104063879400600302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052026899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-79-5-961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060360831"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-04-06T00:00", 
    "description": "

The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.

", "id": "sg:patent.US-7691389-B2", "keywords": [ "infectious cDNA clone", "Porcine Reproductive and Respiratory Syndrome", "virus", "invention", "polynucleotides", "plasmid", "viral vector", "host cell", "Base Sequence", "sequence", "RNA molecule", "vaccine", "method", "swine", "animal", "peptide", "virion" ], "name": "Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.463103.3", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.410513.2", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-7691389-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:05", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00043.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7691389-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7691389-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7691389-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7691389-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

95 TRIPLES      15 PREDICATES      46 URIs      25 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-7691389-B2 schema:about anzsrc-for:3114
2 schema:author N58aee04b6d4b47b7be8be1aebf560c1b
3 schema:citation sg:pub.10.1007/bf01313785
4 sg:pub.10.1007/bf01322667
5 sg:pub.10.1007/bf01322671
6 sg:pub.10.1007/s007050050316
7 https://doi.org/10.1002/pat.1992.220030602
8 https://doi.org/10.1006/viro.1993.1008
9 https://doi.org/10.1016/0168-1702(95)01305-9
10 https://doi.org/10.1016/s0168-1702(97)00134-2
11 https://doi.org/10.1073/pnas.94.3.991
12 https://doi.org/10.1080/01652176.1991.9694296
13 https://doi.org/10.1080/01652176.1991.9694297
14 https://doi.org/10.1099/0022-1317-79-5-961
15 https://doi.org/10.1177/104063879200400201
16 https://doi.org/10.1177/104063879400600302
17 schema:datePublished 2010-04-06T00:00
18 schema:description <p num="p-0001">The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.</p>
19 schema:keywords Base Sequence
20 Porcine Reproductive and Respiratory Syndrome
21 RNA molecule
22 animal
23 host cell
24 infectious cDNA clone
25 invention
26 method
27 peptide
28 plasmid
29 polynucleotides
30 sequence
31 swine
32 vaccine
33 viral vector
34 virion
35 virus
36 schema:name Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
37 schema:recipient https://www.grid.ac/institutes/grid.410513.2
38 https://www.grid.ac/institutes/grid.463103.3
39 schema:sameAs https://app.dimensions.ai/details/patent/US-7691389-B2
40 schema:sdDatePublished 2019-04-18T10:05
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher N3c50dfcc6b82497e9fefba8ae112639a
43 sgo:license sg:explorer/license/
44 sgo:sdDataset patents
45 rdf:type sgo:Patent
46 N0d457f43379843a894ab9ee6c5c0e9ae rdf:first Nf9a85ca1060d4b70a2cb58bd6122cefc
47 rdf:rest Neea28323d93443bdabffb228ebdb03ad
48 N286fd3b75b604c3aaf73dc6c4614ca82 schema:name Siao-Kun W. Welch
49 rdf:type schema:Person
50 N3c50dfcc6b82497e9fefba8ae112639a schema:name Springer Nature - SN SciGraph project
51 rdf:type schema:Organization
52 N4140cf2db5a04c33851da54187124316 schema:name Jay Gregory Calvert
53 rdf:type schema:Person
54 N58aee04b6d4b47b7be8be1aebf560c1b rdf:first N4140cf2db5a04c33851da54187124316
55 rdf:rest N0d457f43379843a894ab9ee6c5c0e9ae
56 Neea28323d93443bdabffb228ebdb03ad rdf:first N286fd3b75b604c3aaf73dc6c4614ca82
57 rdf:rest rdf:nil
58 Nf9a85ca1060d4b70a2cb58bd6122cefc schema:name Michael G Sheppard
59 rdf:type schema:Person
60 anzsrc-for:3114 schema:inDefinedTermSet anzsrc-for:
61 rdf:type schema:DefinedTerm
62 sg:pub.10.1007/bf01313785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019690322
63 https://doi.org/10.1007/bf01313785
64 rdf:type schema:CreativeWork
65 sg:pub.10.1007/bf01322667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016657513
66 https://doi.org/10.1007/bf01322667
67 rdf:type schema:CreativeWork
68 sg:pub.10.1007/bf01322671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011815838
69 https://doi.org/10.1007/bf01322671
70 rdf:type schema:CreativeWork
71 sg:pub.10.1007/s007050050316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047361885
72 https://doi.org/10.1007/s007050050316
73 rdf:type schema:CreativeWork
74 https://doi.org/10.1002/pat.1992.220030602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040892609
75 rdf:type schema:CreativeWork
76 https://doi.org/10.1006/viro.1993.1008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048337583
77 rdf:type schema:CreativeWork
78 https://doi.org/10.1016/0168-1702(95)01305-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047336278
79 rdf:type schema:CreativeWork
80 https://doi.org/10.1016/s0168-1702(97)00134-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013396267
81 rdf:type schema:CreativeWork
82 https://doi.org/10.1073/pnas.94.3.991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008689203
83 rdf:type schema:CreativeWork
84 https://doi.org/10.1080/01652176.1991.9694296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041373192
85 rdf:type schema:CreativeWork
86 https://doi.org/10.1080/01652176.1991.9694297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043183788
87 rdf:type schema:CreativeWork
88 https://doi.org/10.1099/0022-1317-79-5-961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060360831
89 rdf:type schema:CreativeWork
90 https://doi.org/10.1177/104063879200400201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031398616
91 rdf:type schema:CreativeWork
92 https://doi.org/10.1177/104063879400600302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052026899
93 rdf:type schema:CreativeWork
94 https://www.grid.ac/institutes/grid.410513.2 schema:Organization
95 https://www.grid.ac/institutes/grid.463103.3 schema:Organization
 




Preview window. Press ESC to close (or click here)


...