Stimuli-responsive hydrogel microdomes integrated with genetically engineered proteins for high-throughput screening of pharmaceuticals


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Sylvia Daunert , Sapna Kamlakar Deo , Jason Douglas Ehrick , Tyler William Browning , Leonidas G. Bachas

ABSTRACT

A hydrogel microdome that can swell in response to a stimuli or target molecule is formed by polymerizing a mixture comprising a monomer capable of forming a hydrogel with a biopolymer. An array of hydrogel microdomes can be formed on a substrate by microspotting the mixture and polymerizing. The array can be used for high-throughput screening of analytes as well as for use as an actuator and biosensor using the swelling property of the hydrogel. More... »

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