DNA vaccination for treatment of multiple sclerosis and insulin-dependent diabetes mellitus


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Lawrence Steinman , Pedro Ruiz , Hideki Garren

ABSTRACT

A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-γ and IL-15, are reduced. More... »

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