Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA)


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead

ABSTRACT

The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Keith P. Wilson", 
        "type": "Person"
      }, 
      {
        "name": "Michael D. Sintchak", 
        "type": "Person"
      }, 
      {
        "name": "Mark Andrew Fleming", 
        "type": "Person"
      }, 
      {
        "name": "David M. Armistead", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/prot.340230417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008342362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0040-4020(01)86503-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012043959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889891004430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014185292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340190305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015463775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340080302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017148495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340110409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018291810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(82)90153-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018405207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340110104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027707222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(93)81629-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031530811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328496a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033580843", 
          "https://doi.org/10.1038/328496a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.540130412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037162566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199503150-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039593515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/221235a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041115847", 
          "https://doi.org/10.1038/221235a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-440x(92)90147-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041217345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00124349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041406450", 
          "https://doi.org/10.1007/bf00124349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00124349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041406450", 
          "https://doi.org/10.1007/bf00124349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00126441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048511741", 
          "https://doi.org/10.1007/bf00126441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00126441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048511741", 
          "https://doi.org/10.1007/bf00126441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/qsar.19820010102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048625208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00124387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049316994", 
          "https://doi.org/10.1007/bf00124387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00124387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049316994", 
          "https://doi.org/10.1007/bf00124387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(95)06088-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049842056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81275-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051526802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00042a021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055158482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00145a002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055936611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00165a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055937436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00349a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055944692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm950600m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055957207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/6.6.615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059980890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2493678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062540329"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "description": "

The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

", "id": "sg:patent.US-7527952-B2", "keywords": [ "crystal", "Inosine Monophosphate", "invention", "storage medium", "molecule", "molecular complex", "binding pocket", "IMPDH", "storage material", "homologues", "three-dimensional representation", "computer screen", "method", "homologous protein", "protein complex", "screen", "design compound", "inhibitory compound", "compound", "pharmaceutical", "inhibitor" ], "name": "Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA)", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.422219.e", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-7527952-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:34", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_83943d3a.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-7527952-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-7527952-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-7527952-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-7527952-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

140 TRIPLES      14 PREDICATES      61 URIs      28 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-7527952-B2 schema:about anzsrc-for:2581
2 schema:author N8ad026fa0da44df6a9af17636d120759
3 schema:citation sg:pub.10.1007/bf00124349
4 sg:pub.10.1007/bf00124387
5 sg:pub.10.1007/bf00126441
6 sg:pub.10.1038/221235a0
7 sg:pub.10.1038/328496a0
8 https://doi.org/10.1002/jcc.540130412
9 https://doi.org/10.1002/prot.340080302
10 https://doi.org/10.1002/prot.340110104
11 https://doi.org/10.1002/prot.340110409
12 https://doi.org/10.1002/prot.340190305
13 https://doi.org/10.1002/prot.340230417
14 https://doi.org/10.1002/qsar.19820010102
15 https://doi.org/10.1016/0009-8981(95)06088-u
16 https://doi.org/10.1016/0014-5793(93)81629-e
17 https://doi.org/10.1016/0022-2836(82)90153-x
18 https://doi.org/10.1016/0959-440x(92)90147-y
19 https://doi.org/10.1016/s0040-4020(01)86503-0
20 https://doi.org/10.1016/s0092-8674(00)81275-1
21 https://doi.org/10.1021/bi00042a021
22 https://doi.org/10.1021/jm00145a002
23 https://doi.org/10.1021/jm00165a001
24 https://doi.org/10.1021/jm00349a003
25 https://doi.org/10.1021/jm950600m
26 https://doi.org/10.1093/protein/6.6.615
27 https://doi.org/10.1097/00007890-199503150-00002
28 https://doi.org/10.1107/s0021889891004430
29 https://doi.org/10.1126/science.2493678
30 schema:description <p num="p-0001">The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.</p>
31 schema:keywords IMPDH
32 Inosine Monophosphate
33 binding pocket
34 compound
35 computer screen
36 crystal
37 design compound
38 homologous protein
39 homologues
40 inhibitor
41 inhibitory compound
42 invention
43 method
44 molecular complex
45 molecule
46 pharmaceutical
47 protein complex
48 screen
49 storage material
50 storage medium
51 three-dimensional representation
52 schema:name Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA)
53 schema:recipient https://www.grid.ac/institutes/grid.422219.e
54 schema:sameAs https://app.dimensions.ai/details/patent/US-7527952-B2
55 schema:sdDatePublished 2019-03-07T15:34
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N68eb00f338cc4d6e84a53b85bd7ed10b
58 sgo:license sg:explorer/license/
59 sgo:sdDataset patents
60 rdf:type sgo:Patent
61 N0755d755e97d4dd9a7640c7597fef766 schema:name Mark Andrew Fleming
62 rdf:type schema:Person
63 N4acb446c2f014453b35cec9df22f4575 rdf:first N0755d755e97d4dd9a7640c7597fef766
64 rdf:rest N8076640b0d154562af1ea89e50cada57
65 N68eb00f338cc4d6e84a53b85bd7ed10b schema:name Springer Nature - SN SciGraph project
66 rdf:type schema:Organization
67 N8076640b0d154562af1ea89e50cada57 rdf:first Nee9941181bab4c28b8b23bbad0fd2bf8
68 rdf:rest rdf:nil
69 N8ad026fa0da44df6a9af17636d120759 rdf:first Nb5ef5c986c40462db4ed4fffc6be028a
70 rdf:rest Nf6f380cca13441d4be733ad89fa0e2c5
71 Nb5ef5c986c40462db4ed4fffc6be028a schema:name Keith P. Wilson
72 rdf:type schema:Person
73 Nee56f45a89584d789b223ad489081a63 schema:name Michael D. Sintchak
74 rdf:type schema:Person
75 Nee9941181bab4c28b8b23bbad0fd2bf8 schema:name David M. Armistead
76 rdf:type schema:Person
77 Nf6f380cca13441d4be733ad89fa0e2c5 rdf:first Nee56f45a89584d789b223ad489081a63
78 rdf:rest N4acb446c2f014453b35cec9df22f4575
79 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
80 rdf:type schema:DefinedTerm
81 sg:pub.10.1007/bf00124349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041406450
82 https://doi.org/10.1007/bf00124349
83 rdf:type schema:CreativeWork
84 sg:pub.10.1007/bf00124387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049316994
85 https://doi.org/10.1007/bf00124387
86 rdf:type schema:CreativeWork
87 sg:pub.10.1007/bf00126441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048511741
88 https://doi.org/10.1007/bf00126441
89 rdf:type schema:CreativeWork
90 sg:pub.10.1038/221235a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041115847
91 https://doi.org/10.1038/221235a0
92 rdf:type schema:CreativeWork
93 sg:pub.10.1038/328496a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033580843
94 https://doi.org/10.1038/328496a0
95 rdf:type schema:CreativeWork
96 https://doi.org/10.1002/jcc.540130412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037162566
97 rdf:type schema:CreativeWork
98 https://doi.org/10.1002/prot.340080302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017148495
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1002/prot.340110104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027707222
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1002/prot.340110409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018291810
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1002/prot.340190305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015463775
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1002/prot.340230417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008342362
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1002/qsar.19820010102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048625208
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1016/0009-8981(95)06088-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1049842056
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1016/0014-5793(93)81629-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1031530811
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1016/0022-2836(82)90153-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018405207
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1016/0959-440x(92)90147-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1041217345
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1016/s0040-4020(01)86503-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012043959
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1016/s0092-8674(00)81275-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051526802
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1021/bi00042a021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055158482
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1021/jm00145a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055936611
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1021/jm00165a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055937436
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1021/jm00349a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055944692
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1021/jm950600m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055957207
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1093/protein/6.6.615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059980890
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1097/00007890-199503150-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039593515
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1107/s0021889891004430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014185292
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1126/science.2493678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062540329
139 rdf:type schema:CreativeWork
140 https://www.grid.ac/institutes/grid.422219.e schema:Organization
 




Preview window. Press ESC to close (or click here)


...