Etomoxir and a 2-deoxy-D-glucose compound; antiinflammatory, antiproliferative, anticarcinogenic and wound healing agents; drug resistant cancers


Ontology type: sgo:Patent     


Patent Info

DATE

2009-03-31T00:00

AUTHORS

NEWELL MARTHA KAREN , NEWELL EVAN , VILLOBOS-MENVEY ELIZABETH

ABSTRACT

Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a therapeutically acceptable amount of a fatty acid metabolism inhibitor and/or a therapeutically acceptable amount of a glucose metabolism inhibitor, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an antibody against UCP and/or Fas antigen with an oxirane carboxylic acid, represented by etomoxir, and/or with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers. More... »

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