Screening assay based on the forkhead transcription factor-dependent sod-3 promoter


Ontology type: sgo:Patent     


Patent Info

DATE

2008-10-14T00:00

AUTHORS

HOPPE EDMUND , SIEBERS ULRIKE , SCHAUERTE HEIKE , ROTHBLATT JONATHAN

ABSTRACT

The invention relates to the identification and use of the DAF-2/IR responsive sod-3 promoter. Transgenic C. elegans containing sod-3 reporter gene constructs are described which are useful for, among other things, the identification of genes or compounds capable of modulating the DAF-2/IR-akt pathway. Conditions are disclosed that increase or decrease the reporter activity, demonstrating the presence of either activators or inhibitors of the DAF-2/IR pathway. More... »

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