Modulation of biological signal transduction by RNA interference


Ontology type: sgo:Patent     


Patent Info

DATE

2008-07-15T00:00

AUTHORS

Richard Klinghoffer , Stephen Patrick Lewis

ABSTRACT

Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that interfere with expression of members of the protein tyrosine phosphatase (PTP) class of enzymes that mediate signal transduction, and with certain MAP kinase kinases (MKK). In certain preferred embodiments siRNA modulate signal transduction pathways comprising SHP2, cdc14a/b, cdc25A/B/C, KAP, PTP-ε, PRL-3, CD45, dual specificity phosphatase-3 (DSP-3), MKK-4, and/or MKK-7. Modulation of PTP-mediated biological signal transduction has uses in diseases associated with defects in cell proliferation, cell differentiation and/or cell survival, such as metabolic disorders (including diabetes and obesity), cancer, autoimmune disease, infectious and inflammatory disorders and other conditions. The invention also provides siRNA polynucleotides that interfere with expression of chemotherapeutic target polypeptides, such as DHFR, thymidylate synthetase, and topoisomerase I. More... »

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60 schema:description <p num="p-0001">Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that interfere with expression of members of the protein tyrosine phosphatase (PTP) class of enzymes that mediate signal transduction, and with certain MAP kinase kinases (MKK). In certain preferred embodiments siRNA modulate signal transduction pathways comprising SHP2, cdc14a/b, cdc25A/B/C, KAP, PTP-&#949;, PRL-3, CD45, dual specificity phosphatase-3 (DSP-3), MKK-4, and/or MKK-7. Modulation of PTP-mediated biological signal transduction has uses in diseases associated with defects in cell proliferation, cell differentiation and/or cell survival, such as metabolic disorders (including diabetes and obesity), cancer, autoimmune disease, infectious and inflammatory disorders and other conditions. The invention also provides siRNA polynucleotides that interfere with expression of chemotherapeutic target polypeptides, such as DHFR, thymidylate synthetase, and topoisomerase I.</p>
61 schema:keywords CD45
62 DHFR
63 MAP Kinase Kinase 4
64 MAP kinase
65 Mitogen-Activated Protein Kinase Kinase
66 Neoplasm
67 RNA interference
68 Shp2
69 Small Interfering RNA
70 autoimmune disease
71 cell differentiation
72 cell proliferation
73 cell survival
74 chemotherapeutic target
75 class
76 composition
77 condition
78 defect
79 diabetes
80 disease
81 dual specificity
82 enzyme
83 expression
84 inflammatory disorder
85 invention
86 kap
87 metabolic disorder
88 method
89 modulation
90 obesity
91 pertains
92 polynucleotides
93 protein tyrosine phosphatase
94 signal transduction
95 thymidylate synthase
96 topoisomerase
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