Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy


Ontology type: sgo:Patent     


Patent Info

DATE

2008-07-08T00:00

AUTHORS

YAN GAN-XIN

ABSTRACT

Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound. More... »

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